Asymmetric Histone Inheritance: Establishment, Recognition, and Execution.
Asymmetric Histone Inheritance: Establishment, Recognition, and Execution.
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DOI：
10.1146/annurev-genet-072920-125226
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发表时间：
2022-11-30
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
在不对称分裂的果蝇雄性生殖系干细胞中发现不对称组蛋白遗传，表明了引入细胞多样性的机制。这一过程被认为分三个步骤进行：第一，姐妹染色单体之间组蛋白不对称的建立;第二，识别携带不对称表观遗传信息的姐妹染色单体;第三，在所产生的子细胞中执行不对称表观基因组。组蛋白伴侣和复制体组分影响复制偶联的组蛋白组装到姐妹染色单体上，这对于维持表观遗传记忆和基因组完整性是重要的。不对称表观基因组的识别涉及以姐妹着丝粒不对称为中心的“有丝分裂驱动”机制，其中着丝粒蛋白水平和微管活性的差异偏向于表观遗传学上不同的姐妹染色单体的遗传。最后，表观基因组的差异差异影响细胞周期进程和可能的基因表达的子细胞。这篇综述讨论了每个步骤的现有知识，以及这一过程如何有助于多细胞生物中的细胞命运决定。
The discovery of asymmetric histone inheritance during asymmetrically dividing Drosophila melanogaster male germline stem cells indicates a mechanism for introducing cellular diversity. This process is proposed to occur in three steps: First, establishment of histone asymmetry between sister chromatids; second, recognition of sister chromatids carrying asymmetric epigenetic information; and third, execution of the asymmetric epigenome in the resulting daughter cells. Histone chaperones and replisome components influence replication-coupled histone assembly onto sister chromatids, which is important for maintaining epigenetic memory and genomic integrity. Recognition of the asymmetric epigenome involves a sister centromere asymmetry-centered ‘mitotic drive’ mechanism, where differences in centromere protein levels and asynchronized microtubule activity bias inheritance of epigenetically distinct sister chromatids. Finally, differences in epigenomes differentially influence cell cycle progression and likely gene expression in the daughter cells. This review discusses current knowledge for each step and how this process contributes to the cell fate determination in multicellular organisms.
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影响因子：
10.5
作者：
Alabert C;Barth TK;Reverón-Gómez N;Sidoli S;Schmidt A;Jensen ON;Imhof A;Groth A
通讯作者：
Groth A
DOI：
10.1080/15384101.2018.1515555
发表时间：
2018
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Chan YW;West SC
通讯作者：
West SC
影响因子：
16
作者：
Bellelli R;Belan O;Pye VE;Clement C;Maslen SL;Skehel JM;Cherepanov P;Almouzni G;Boulton SJ
通讯作者：
Boulton SJ
影响因子：
16.8
作者：
Burgess, Rebecca J.;Zhang, Zhiguo
通讯作者：
Zhang, Zhiguo
影响因子：
64.8
作者：
Buchwitz, BJ;Ahmad, K;Henikoff, S
通讯作者：
Henikoff, S