Dietary Fructose and Fructose-Induced Pathologies.

Dietary Fructose and Fructose-Induced Pathologies.
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饮食果糖和果糖诱导的病理。

DOI:
10.1146/annurev-nutr-062220-025831
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发表时间:
2022-08-22
影响因子:
8.9
通讯作者:
--
中科院分区:
医学2区
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--
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在过去的几十年里,果糖作为糖和高果糖玉米糖浆的消费量显着增加。这一趋势与代谢性疾病的指数上升相吻合,包括肥胖、非酒精性脂肪肝、心血管疾病和糖尿病。虽然果糖代谢的生物化学途径在20世纪90年代初就已阐明,但生物体水平的果糖代谢及其全身病理生理学影响最近才得到研究。在这篇综述中,我们讨论了果糖消耗的历史,不同器官和肠道微生物群中果糖代谢的生化和分子途径,果糖在代谢性疾病发病机制中的作用,以及治疗此类疾病的剩余问题。
The consumption of fructose as sugar and high-fructose corn syrup has markedly increased during the past several decades. This trend coincides with the exponential rise of metabolic diseases, including obesity, nonalcoholic fatty liver disease, cardiovascular disease, and diabetes. While the biochemical pathways of fructose metabolism were elucidated in the early 1990s, organismal-level fructose metabolism and its whole-body pathophysiological impacts have been only recently investigated. In this review, we discuss the history of fructose consumption, biochemical and molecular pathways involved in fructose metabolism in different organs and gut microbiota, the role of fructose in the pathogenesis of metabolic diseases, and the remaining questions to treat such diseases.
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