BNP as a New Biomarker of Cardiac Thyroid Hormone Function
BNP as a New Biomarker of Cardiac Thyroid Hormone Function
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BNP 作为心脏甲状腺激素功能的新生物标志物
DOI：
10.3389/fphys.2020.00729
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发表时间：
2020-07
影响因子：
4
通讯作者：
Gerdes Anthony Martin
中科院分区：
文献类型：
--
作者：
Wang Kaihao;Ojamaa Kaie;Samuels Abigail;Gilani Nimra;Zhang Kuo;An Shimin;Zhang Youhua;Tang Yi-Da;Askari Bardia;Gerdes Anthony Martin
心力衰竭（HF）患者心脏胎儿基因的重新表达提示心脏组织甲状腺激素（TH）功能低下。然而，T3和T4的血清浓度通常是正常的或亚临床低的，因此需要针对低心脏TH功能的替代血清生物标志物来指导这些患者的治疗。临床文献表明，血清脑钠肽（BNP）水平与血清三碘-L-甲状腺原氨酸（T3）水平呈负相关。本研究的目的是探讨BNP作为心脏TH功能的潜在血清生物标志物。方法建立两种甲状腺激素缺乏症动物模型：（1）丙基硫氧嘧啶诱导的成年雌性大鼠甲状腺功能减退症（Hypo）8周后，口服T3（10 μ g/kg/d），持续3、6或14天;（2）冠状动脉结扎致HF（心肌梗死，MI）的成年雌性大鼠每天口服低剂量T3（5 μ g/kg/d）8或16 wk. Results 6天的T3治疗Hypo大鼠正常化大多数心脏功能参数。低血糖大鼠的BNP血清水平增加了5倍，而T3治疗使BNP在第14天恢复正常，表明血清BNP与游离或总T3浓度之间存在显著的负相关关系。心肌BNP mRNA在Hypo大鼠中增加2.5倍，并且其表达在T3治疗14天时降低至正常值。心肌梗死16周后，血流动力学功能检测显示心肌梗死大鼠明显功能障碍，血清BNP升高4.5倍，血清游离T3和总T3显著降低。T3治疗降低了血清BNP水平，同时增加了总T3水平，表明这两个生物学因素之间呈负相关（r（2）= 0.676，p < 0.001）。心肌BNP mRNA在MI大鼠中增加5倍，在8至16周的治疗期间，T3显著降低心肌BNP mRNA。结论两种TH功能障碍模型的结果证实了组织和血清T3与BNP之间的负相关关系，因此血清BNP的降低可能用于监测T3治疗的疗效和剂量。因此，血清BNP可作为心脏TH功能的可靠生物标志物。
Background Cardiac re-expression of fetal genes in patients with heart failure (HF) suggests the presence of low cardiac tissue thyroid hormone (TH) function. However, serum concentrations of T3 and T4 are often normal or subclinically low, necessitating an alternative serum biomarker for low cardiac TH function to guide treatment of these patients. The clinical literature suggests that serum Brain Natriuretic Peptide (BNP) levels are inversely associated with serum triiodo-L-thyronine (T3) levels. The objective of this study was to investigate BNP as a potential serum biomarker for TH function in the heart. Methods Two animal models of thyroid hormone deficiency: (1) 8-weeks of propyl thiouracil-induced hypothyroidism (Hypo) in adult female rats were subsequently treated with oral T3 (10 mu g/kg/d) for 3, 6, or 14 days; (2) HF induced by coronary artery ligation (myocardial infarction, MI) in adult female rats was treated daily with low dose oral T3 (5 mu g/kg/d) for 8 or 16 wks. Results Six days of T3 treatment of Hypo rats normalized most cardiac functional parameters. Serum levels of BNP increased 5-fold in Hypo rats, while T3 treatment normalized BNP by day 14, showing a significant inverse relationship between serum BNP and free or total T3 concentrations. Myocardial BNP mRNA was increased 2.5-fold in Hypo rats and its expression was decreased to normal values by 14 days of T3 treatment. Measurements of hemodynamic function showed significant dysfunction in MI rats after 16 weeks, with serum BNP increased by 4.5-fold and serum free and total T3 decreased significantly. Treatment with T3 decreased serum BNP while increasing total T3 indicating an inverse correlation between these two biologic factors (r(2)= 0.676,p< 0.001). Myocardial BNP mRNA was increased 5-fold in MI rats which was significantly decreased by T3 over 8 to 16 week treatment periods. Conclusions Results from the two models of TH dysfunction confirmed an inverse relationship between tissue and serum T3 and BNP, such that the reduction in serum BNP could potentially be utilized to monitor efficacy and dosing of T3 treatment. Thus, serum BNP may serve as a reliable biomarker for cardiac TH function.
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影响因子：
2.7
作者：
Bunevicius, R;Varoneckas, G;Girdler, SS
通讯作者：
Girdler, SS
DOI：
10.1007/s00018-017-2737-0
发表时间：
2018-04
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
Man J;Barnett P;Christoffels VM
通讯作者：
Christoffels VM
DOI：
10.1152/ajpheart.00431.2015
发表时间：
2015-09
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
N. Weltman;C. Pol;Youhua Zhang;Yibo Wang;Adrienne Koder;Sarah Raza;R. Zucchi;A. Saba;Daria Colli
通讯作者：
N. Weltman;C. Pol;Youhua Zhang;Yibo Wang;Adrienne Koder;Sarah Raza;R. Zucchi;A. Saba;Daria Colli
影响因子：
13
作者：
Daubert, Melissa A.;Adams, Kirkwood;Felker, G. Michael
通讯作者：
Felker, G. Michael
影响因子：
37.8
作者：
Di Angelantonio, Emanuele;Chowdhury, Rajiv;Danesh, John
通讯作者：
Danesh, John