Structure and function of the Nppa-Nppb cluster locus during heart development and disease.
Structure and function of the Nppa-Nppb cluster locus during heart development and disease.
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DOI：
10.1007/s00018-017-2737-0
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Christoffels VM
中科院分区：
文献类型：
--
作者：
Man J;Barnett P;Christoffels VM
心钠素和脑钠素是临床心血管病中两种重要的生物标志物。这两种利钠肽激素由进化保守的旁系同源基因Nppa和Nppb编码。这两种基因在胚胎和胎儿阶段主要由心肌表达，特别是出生后心室中的Nppa表达强烈降低。在心脏应激时，Nppa和Nppb在心室心肌中强烈上调。关于诱导Nppa和Nppb表达的分子和生理学原因已经知道很多;然而，Nppa-Nppb簇在体内的转录调控机制已被证明是相当复杂的，并且还没有被很好地理解。在这篇综述中，我们将提供最新的见解Nppa和Nppb在心脏发育和肥大的动态和复杂的调节，以及该基因簇与心脏再生的心肌细胞内在程序的关联。
Atrial natriuretic factor and brain natriuretic peptide are two important biomarkers in clinical cardiology. These two natriuretic peptide hormones are encoded by the paralogous genes Nppa and Nppb, which are evolutionary conserved. Both genes are predominantly expressed by the heart muscle during the embryonic and fetal stages, and in particular Nppa expression is strongly reduced in the ventricles after birth. Upon cardiac stress, Nppa and Nppb are strongly upregulated in the ventricular myocardium. Much is known about the molecular and physiological ques inducing Nppa and Nppb expression; however, the transcriptional regulatory mechanisms of the Nppa–Nppb cluster in vivo has proven to be quite complex and is not well understood. In this review, we will provide recent insights into the dynamic and complex regulation of Nppa and Nppb during heart development and hypertrophy, and the association of this gene cluster with the cardiomyocyte-intrinsic program of heart regeneration.
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