Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice.
Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice.
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笼内的等级制度影响群养 C57BL/6 雄性小鼠的行为和基因表达。
DOI：
10.1038/s41598-017-07233-5
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发表时间：
2017-08-01
影响因子：
4.6
通讯作者：
Koide T
中科院分区：
文献类型：
--
作者：
Horii Y;Nagasawa T;Sakakibara H;Takahashi A;Tanave A;Matsumoto Y;Nagayama H;Yoshimi K;Yasuda MT;Shimoi K;Koide T
群居的雄性小鼠对笼中的配偶表现出攻击性行为，并形成社会等级。在这里，我们描述了如何在标准组圈养条件下的社会等级影响雄性小鼠的行为和基因表达。在研究中使用的每个笼子中饲养四只雄性C57BL/6小鼠，并且通过观察攻击行为的视频记录来确定社会等级。在形成社会等级后，分析了小鼠的行为和海马基因表达。与显性小鼠相比，在从属小鼠中观察到更高的焦虑和抑郁样行为以及下丘脑促肾上腺皮质激素释放激素和海马5-羟色胺受体亚型的基因表达升高。这些差异通过口服氟西汀缓解，氟西汀是一种选择性5-羟色胺再摄取抑制剂类抗抑郁药。我们的结论是，家庭笼中的等级制度影响雄性小鼠的行为和基因表达，导致焦虑和抑郁样行为在显性和从属小鼠中受到不同的调节。
Group-housed male mice exhibit aggressive behaviour towards their cage mates and form a social hierarchy. Here, we describe how social hierarchy in standard group-housed conditions affects behaviour and gene expression in male mice. Four male C57BL/6 mice were kept in each cage used in the study, and the social hierarchy was determined from observation of video recordings of aggressive behaviour. After formation of a social hierarchy, the behaviour and hippocampal gene expression were analysed in the mice. Higher anxiety- and depression-like behaviours and elevated gene expression of hypothalamic corticotropin-releasing hormone and hippocampal serotonin receptor subtypes were observed in subordinate mice compared with those of dominant mice. These differences were alleviated by orally administering fluoxetine, which is an antidepressant of the selective serotonin reuptake inhibitor class. We concluded that hierarchy in the home cage affects behaviour and gene expression in male mice, resulting in anxiety- and depression-like behaviours being regulated differently in dominant and subordinate mice.
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影响因子：
3.3
作者：
Eckart, S.;Hoertnag, H.;Hellweg, R.
通讯作者：
Hellweg, R.
影响因子：
3
作者：
Henriques-Alves AM;Queiroz CM
通讯作者：
Queiroz CM
DOI：
10.1073/pnas.0810793106
发表时间：
2009-06-23
影响因子：
11.1
作者：
Alenina, Natalia;Kikic, Dana;Bader, Michael
通讯作者：
Bader, Michael
影响因子：
3.7
作者：
Duncko, R;Kiss, A;Jezová, D
通讯作者：
Jezová, D
影响因子：
25
作者：
Kheirbek, Mazen A.;Klemenhagen, Kristen C.;Sahay, Amar;Hen, Rene
通讯作者：
Hen, Rene