Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders.
Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders.
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DOI：
10.1038/nn.3262
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发表时间：
2012-12
影响因子：
25
通讯作者：
Hen, Rene
中科院分区：
文献类型：
--
作者：
Kheirbek, Mazen A.;Klemenhagen, Kristen C.;Sahay, Amar;Hen, Rene
尽管近年来成人神经发生在介导抗抑郁药的某些作用中的影响受到了相当大的关注，但关于这种形式的可塑性的改变如何导致焦虑和抑郁等精神疾病的研究却知之甚少。开始解决这个问题的一种方法是将成年海马神经元的功能与这些疾病的特定内表型联系起来。最近的研究表明，成年海马神经元参与了模式分离，这是一个将相似的经历或事件转化为离散的、不重叠的表征的过程。在这里，我们提出，受损的模式分离的基础上过度概括经常看到焦虑症，特别是创伤后应激障碍和恐慌症，因此代表了这些疾病的内在表型。因此，开发新的前神经源性化合物可能对显示模式分离缺陷的患者具有治疗潜力。
Although an influence of adult neurogenesis in mediating some of the effects of antidepressants has received considerable attention in recent years, much less is known about how alterations in this form of plasticity may contribute to psychiatric disorders such as anxiety and depression. One way to begin to address this question is to link the functions of adult-born hippocampal neurons with specific endophenotypes of these disorders. Recent studies have implicated adult-born hippocampal neurons in pattern separation, a process by which similar experiences or events are transformed into discrete, non-overlapping representations. Here we propose that impaired pattern separation underlies the overgeneralization often seen in anxiety disorders, specifically post-traumatic stress disorder and panic disorder, and therefore represents an endophenotype for these disorders. The development of new, pro-neurogenic compounds may therefore have therapeutic potential for patients who display pattern separation deficits.
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