Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum.
Primary food reward and reward-predictive stimuli evoke different patterns of phasic dopamine signaling throughout the striatum.
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DOI：
10.1111/j.1460-9568.2011.07914.x
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发表时间：
2011-12
期刊：
影响因子：
--
通讯作者：
Roitman MF
中科院分区：
文献类型：
--
作者：
Brown HD;McCutcheon JE;Cone JJ;Ragozzino ME;Roitman MF
多巴胺活动的阶段性变化在学习和目标导向行为中起着关键作用。不可预测的奖励和奖励预测线索引起大多数中脑多巴胺神经元放电率的阶段性增加--结果预测整个纹状体多巴胺浓度的均匀广播增加。然而，对奖赏过程中多巴胺浓度变化的测量对这一预测提出了质疑。我们系统地测量了四个纹状体亚区（核壳（壳）和核心（核心），背内侧（DMS）和背外侧纹状体（DLS））的多巴胺的阶段性变化，已知激活大多数多巴胺神经元的刺激。我们在清醒和正常的大鼠中使用快速扫描循环伏安法，该方法在与电生理记录相似的时间尺度上测量多巴胺的变化，该记录建立了阶段性多巴胺活动和奖励之间的关系。与中脑多巴胺神经元的反应不同，不可预测的食物奖励和奖励预测线索诱发了多巴胺的阶段性增加，这是亚区域特异性的。在经验有限的大鼠中，不可预测的食物奖励引起了核心的增加。在大鼠训练的歧视性刺激范式，不可预测的奖励和奖励预测线索诱发强大的阶段性多巴胺的核心和DMS。因此，选择目标结构中的阶段性多巴胺释放是动态的，并取决于上下文和经验。由于这四个亚区接受不同的输入，并有不同的投射目标，多巴胺阶段性变化的区域选择性具有重要意义的信息流通过纹状体和可塑性，学习和目标导向的行为。
Phasic changes in dopamine activity play a critical role in learning and goal-directed behavior. Unpredicted reward and reward predictive cues evoke phasic increases in the firing rate of the majority of midbrain dopamine neurons – results that predict uniformly broadcast increases in dopamine concentration throughout the striatum. However, measurement of dopamine concentration changes during reward has cast doubt on this prediction. We systematically measured phasic changes in dopamine in four striatal subregions (nucleus accumbens shell (Shell) and core (Core), dorsomedial (DMS) and dorsolateral striatum (DLS)) in response to stimuli known to activate a majority of dopamine neurons. We used fast-scan cyclic voltammetry in awake and behaving rats, which measures changes in dopamine on a similar timescale to the electrophysiological recordings that established a relationship between phasic dopamine activity and reward. Unlike the responses of midbrain dopamine neurons, unpredicted food reward and reward-predictive cues evoked a phasic increase in dopamine that was subregion specific. In rats with limited experience, unpredicted food reward evoked an increase exclusively in the Core. In rats trained on a discriminative stimulus paradigm, both unpredicted reward and reward-predictive cues evoked robust phasic dopamine in the Core and DMS. Thus, phasic dopamine release in select target structures is dynamic and dependent on context and experience. Since the four subregions assayed receive different inputs and have differential projection targets, the regional selectivity of phasic changes in dopamine has important implications for information flow through the striatum and plasticity that underlies learning and goal-directed behavior.
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DOI：
10.1523/jneurosci.6588-10.2011
发表时间：
2011-04-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ito R;Hayen A
通讯作者：
Hayen A
影响因子：
5.3
作者：
Bamford, NS;Robinson, S;Meshul, CK
通讯作者：
Meshul, CK
影响因子：
7.6
作者：
Besson, Morgane;Belin, David;Dalley, Jeffrey W.
通讯作者：
Dalley, Jeffrey W.
影响因子：
3.3
作者：
Bassareo, V;Di Chiara, G
通讯作者：
Di Chiara, G
影响因子：
5.3
作者：
CILIAX, BJ;HEILMAN, C;LEVEY, AI
通讯作者：
LEVEY, AI