Immunobiology of the critical asthma syndrome.
Immunobiology of the critical asthma syndrome.
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DOI：
10.1007/s12016-013-8407-6
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发表时间：
2015-03
影响因子：
9.1
通讯作者：
Zeki AA
中科院分区：
文献类型：
--
作者：
Harper RW;Zeki AA
现在人们认识到哮喘包含多种具有不同临床表现的综合征。哮喘治疗的未来改进将需要清楚地描述这些哮喘表型以及这些临床表现背后的细胞机制。在此，我们将描述哮喘生物学的当前知识。这将包括对哮喘和过敏领域的早期先驱的回顾、这项工作如何让我们了解 TH1 和 TH2 细胞因子，以及“卫生假说”的发展。我们将讨论 TH1-TH2 哮喘模型在动物和人类研究中的实用性和局限性，以及这些知识如何解决围绕卫生假说和其他竞争模型的争议。我们将讨论基于对哮喘病理学机制的理解而开发的新疗法，包括这些疗法的成功和缺点。我们将回顾导致“哮喘表型”认识的早期工作。这将包括早期发现哮喘的各种炎症亚型以及这些炎症亚型如何与治疗反应相关。最后，我们将描述哮喘生物学的最新发现，包括气道上皮在哮喘发病机制中的作用、哮喘中重要的可作为新治疗靶点的新型细胞因子，以及新描述的先天免疫细胞的鉴定及其在哮喘中的作用。更好地了解支撑各种哮喘表型的复杂生物学对于我们优化所有患有哮喘和严重哮喘综合征的患者的治疗至关重要。
It is now recognized that asthma incorporates a broad spectrum of syndromes with varying clinical manifestations. Future improvements in asthma treatment will require a clear characterization of these asthma phenotypes and the cellular mechanisms underlying these clinical manifestations. Herein, we will describe the current knowledge of asthma biology. This will include a review of the early pioneers in asthma and allergy, how this work led to our understanding of TH1 and TH2 cytokines, and the development of the “hygiene hypothesis.” We will discuss the utility and limitations of the TH1-TH2 model of asthma in animal and human studies, and how this knowledge addresses controversies surrounding the hygiene hypothesis and other competing models. We will discuss novel therapies that have been developed based on mechanistic understanding of asthma pathobiology, including successes and shortcomings of these therapies. We will review the early work that led to the recognition of “asthma phenotypes.” This will include the early discovery of various inflammatory subtypes in asthma and how these inflammatory subtypes correlate with response to therapy. Finally, we will describe recent discoveries in asthma biology that will include the role of the airway epithelium in asthma pathogenesis, novel cytokines important in asthma that may serve as novel therapeutic targets, and the identification of newly described innate immune cells and their role in asthma. Improved understanding of the complex biology underpinning the various asthma phenotypes is critical for our ability to optimize treatment for all patients that suffer from asthma and critical asthma syndromes.
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影响因子：
14.2
作者：
Corrigan, Chris J.;Wang, Wei;Ying, Sun
通讯作者：
Ying, Sun
影响因子：
14.2
作者：
FRICK, OL;GERMAN, DF;MILLS, J
通讯作者：
MILLS, J
影响因子：
4.8
作者：
Chen, Y;Thai, P;Wu, R
通讯作者：
Wu, R
影响因子：
2.8
作者：
Hashimoto, T;Akiyama, K;Mori, A
通讯作者：
Mori, A
DOI：
10.1165/rcmb.4832
发表时间：
2003-01-01
影响因子：
6.4
作者：
Hellings, PW;Kasran, A;Ceuppens, JL
通讯作者：
Ceuppens, JL