The effect of the stress hormone cortisol on the metatranscriptome of the oral microbiome.
The effect of the stress hormone cortisol on the metatranscriptome of the oral microbiome.
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DOI：
10.1038/s41522-018-0068-z
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发表时间：
2018
影响因子：
9.2
通讯作者：
Frias-Lopez J
中科院分区：
文献类型：
--
作者：
Duran-Pinedo AE;Solbiati J;Frias-Lopez J
微生物群的失衡，也被称为微生物失调，可能会导致一系列不同的疾病。已被证明导致微生物组失调的一个因素是暴露在心理压力源中。在整个进化过程中，人类微生物组发展了感知宿主相关信号的系统，如与这些应激源相关的激素，使它们能够识别环境中的基本变化，从而改变它们的表达基因谱以适应新环境的需要。最广为接受的解释荷尔蒙影响感染结果的能力的理论涉及免疫系统的抑制。共生微生物区系参与了应激源诱导的免疫调节，但其他生物学效应尚不清楚。在这里，我们介绍了皮质醇对口腔社区全社区转录组的影响。我们使用了一种元翻译方法来初步了解这种应激激素引起的代谢变化，以及口腔微生物组的哪些成员对环境中皮质醇的存在做出反应。我们的发现表明，应激激素皮质醇直接诱导口腔微生物组基因表达谱的变化，复制在牙周病及其进展的表达谱中发现的结果。
Imbalances of the microbiome, also referred to as microbial dysbiosis, could lead to a series of different diseases. One factor that has been shown to lead to dysbiosis of the microbiome is exposure to psychological stressors. Throughout evolution microorganisms of the human microbiome have developed systems for sensing host-associated signals such as hormones associated with those stressors, enabling them to recognize essential changes in their environment, thus changing their expression gene profile to fit the needs of the new environment. The most widely accepted theory explaining the ability of hormones to affect the outcome of an infection involves the suppression of the immune system. Commensal microbiota is involved in stressor-induced immunomodulation, but other biological effects are not yet known. Here we present the impact that cortisol had on the community-wide transcriptome of the oral community. We used a metatranscriptomic approach to obtain first insights into the metabolic changes induced by this stress hormone as well as which members of the oral microbiome respond to the presence of cortisol in the environment. Our findings show that the stress hormone cortisol directly induces shifts in the gene expression profiles of the oral microbiome that reproduce results found in the profiles of expression of periodontal disease and its progression.
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