Anogenital distance from birth to 2 years: a population study.
Anogenital distance from birth to 2 years: a population study.
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DOI：
10.1289/ehp.0900881
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发表时间：
2009-11
影响因子：
10.4
通讯作者：
Hughes IA
中科院分区：
文献类型：
--
作者：
Thankamony A;Ong KK;Dunger DB;Acerini CL;Hughes IA
肛门生殖器距离（AGD）在啮齿动物和人类中是两性异形的，在雄性中是2- 2.5倍。它是啮齿动物生殖毒理学研究中雄激素和抗雄激素作用的可靠标志物。关于人类年龄增长障碍的数据很少，没有在婴儿期收集纵向数据。本研究旨在确定男性和女性从出生到2岁的AGD，并将其与其他人体测量指标相关联。婴儿是从剑桥婴儿生长研究中招募的。男性从肛门中心到阴囊基部测量AGD，女性从肛门中心到阴囊后部测量AGD。在出生时以及3、12、18和24个月大时进行测量。数据包括来自463名男性和426名女性足月婴儿的2，168次纵向AGD测量（中位数=每个婴儿2次测量）。出生时平均AGD（± SD）为19.8 ± 6.1 mm（男性）和9.1 ± 2.8 mm（女性）（p < 0.0001）。AGD增加到12个月，在两种性别和性别二型模式。AGD与出生时阴茎长度呈正相关（r = 0.18，p = 0.003），从出生到3个月AGD的增加与阴茎生长相关（r= 0.20，p = 0.001）。我们报告了一个大的英国婴儿期AGD的新的纵向数据。出生队列AGD在所研究的所有年龄段都具有性别二态性。规范性数据的可用性提供了一种手段，利用这一生物标记的雄激素作用的人口研究的影响，环境化学品对生殖器发育。
Anogenital distance (AGD) is sexually dimorphic in rodents and humans, being 2- to 2.5-fold greater in males. It is a reliable marker of androgen and antiandrogen effects in rodent reproductive toxicologic studies. Data on AGD in humans are sparse, with no longitudinal data collected during infancy. This study was designed to determine AGD from birth to 2 years in males and females and relate this to other anthropometric measures. Infants were recruited from the Cambridge Baby Growth Study. AGD was measured from the center of the anus to the base of the scrotum in males and to the posterior fourchette in females. Measurements were performed at birth and at 3, 12, 18, and 24 months of age. Data included 2,168 longitudinal AGD measurements from 463 male and 426 female full-term infants (median = 2 measurements per infant). Mean AGD (± SD) at birth was 19.8 ± 6.1 mm in males and 9.1 ± 2.8 mm in females (p < 0.0001). AGD increased up to 12 months in both sexes and in a sex-dimorphic pattern. AGD was positively correlated with penile length at birth (r = 0.18, p = 0.003) and the increase in AGD from birth to 3 months was correlated with penile growth (r= 0.20, p = 0.001). We report novel, longitudinal data for AGD during infancy in a large U.K. birth cohort. AGD was sex dimorphic at all ages studied. The availability of normative data provides a means of utilizing this biological marker of androgen action in population studies of the effects of environmental chemicals on genital development.
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DOI：
10.1186/1476-069x-3-8
发表时间：
2004-09-13
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Salazar-Martinez E;Romano-Riquer P;Yanez-Marquez E;Longnecker MP;Hernandez-Avila M
通讯作者：
Hernandez-Avila M
影响因子：
3.8
作者：
Virtanen, H E;Rajpert-De Meyts, E;Toppari, J
通讯作者：
Toppari, J
影响因子：
5.1
作者：
CALLEGARI, C;EVERETT, S;BRASEL, JA
通讯作者：
BRASEL, JA
DOI：
10.1111/j.1471-0528.2004.00517.x
发表时间：
2005-05-01
影响因子：
5.8
作者：
Lloyd, J;Crouch, NS;Creighton, SM
通讯作者：
Creighton, SM
影响因子：
3.3
作者：
Gallavan, RH;Holson, JF;Reynolds, VL
通讯作者：
Reynolds, VL