Dichotic sound localization properties of duration-tuned neurons in the inferior colliculus of the big brown bat.

Dichotic sound localization properties of duration-tuned neurons in the inferior colliculus of the big brown bat.
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DOI:
10.3389/fphys.2014.00215
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发表时间:
2014
影响因子:
4
通讯作者:
Faure PA
Faure PA
中科院分区:
医学2区
文献类型:
--
作者:
Sayegh R;Aubie B;Faure PA

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对哺乳动物听觉中脑的持续时间调谐神经元 (DTN) 的电生理学研究通常使用针对对侧耳朵的单耳或自由场声刺激来引起这些细胞的尖峰反应,而致力于检查使用双耳刺激的持续时间调谐的电生理学特性的研究较少。由于下丘(IC)接收来自处理来自每只耳朵的声音的下脑干听觉核团的汇聚输入,因此许多中脑神经元具有由双耳相互作用形成的反应,并且对对于声音定位重要的双耳线索具有选择性。在本研究中,我们使用双耳刺激来改变耳间电平差 (ILD) 和耳间时间差 (ITD) 声学线索,并探索来自大棕蝠 (Eptesicus fuscus) IC 的 DTN 和非 DTN 的双耳相互作用和响应特性。我们的结果表明,DTN 和非 DTN 都可以对双耳刺激产生选择性反应,大多数 IC 神经元表现出某种类型的 ILD 选择性,较少的细胞表现出 ITD 选择性,并且许多神经元同时表现出 ILD 和 ITD 选择性。这项研究首次证明,除了对刺激频率、幅度和持续时间有选择性的尖峰响应之外,来自脊椎动物听觉中脑的 DTN 的时间选择性响应还可以对用于声音定位的双耳线索进行选择性。
Electrophysiological studies on duration-tuned neurons (DTNs) from the mammalian auditory midbrain have typically evoked spiking responses from these cells using monaural or free-field acoustic stimulation focused on the contralateral ear, with fewer studies devoted to examining the electrophysiological properties of duration tuning using binaural stimulation. Because the inferior colliculus (IC) receives convergent inputs from lower brainstem auditory nuclei that process sounds from each ear, many midbrain neurons have responses shaped by binaural interactions and are selective to binaural cues important for sound localization. In this study, we used dichotic stimulation to vary interaural level difference (ILD) and interaural time difference (ITD) acoustic cues and explore the binaural interactions and response properties of DTNs and non-DTNs from the IC of the big brown bat (Eptesicus fuscus). Our results reveal that both DTNs and non-DTNs can have responses selective to binaural stimulation, with a majority of IC neurons showing some type of ILD selectivity, fewer cells showing ITD selectivity, and a number of neurons showing both ILD and ITD selectivity. This study provides the first demonstration that the temporally selective responses of DTNs from the vertebrate auditory midbrain can be selective to binaural cues used for sound localization in addition to having spiking responses that are selective for stimulus frequency, amplitude, and duration.
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