Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves' Ophthalmopathy.
Thickness of Extraocular Muscle and Orbital Fat in MRI Predicts Response to Glucocorticoid Therapy in Graves' Ophthalmopathy.
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MRI 中的眼外肌和眼眶脂肪厚度可预测格雷夫斯眼病对糖皮质激素治疗的反应
DOI：
10.1155/2017/3196059
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发表时间：
2017
影响因子：
2.8
通讯作者：
Xue Y
中科院分区：
文献类型：
--
作者：
Xu L;Li L;Xie C;Guan M;Xue Y
33例活动性、中重度Graves眼病（GO）患者接受4.5 g甲基强的松龙治疗12周，并根据疗效分为两组（反应性和无反应性）。所有患者和10名对照者在基线时进行了眼眶MRI检查。两个GO组之间的基线临床特征无显著差异。两个GO组的眼球突出值均高于对照组，并且反应组高于无反应组。与无反应组相比，反应组的下直肌较厚，眶脂肪较薄。反应组的下直肌/脂肪比显著高于无反应组。多因素Logistic回归分析显示，眼球突出值和下直肌/脂肪比与糖皮质激素（GC）的反应显著相关。ROC分析显示，下直肌/脂肪比与眼球突出值相结合，以表明疗效的临界点为1.42和20.78。对于CAS > 3的中重度GO患者，MRI下直肌/脂肪比值和眼球突出值可能是预测GC治疗反应的有价值的指标。
33 patients with active, moderate-severe Graves' ophthalmopathy (GO) received 4.5 g methylprednisolone for 12 weeks and were divided by efficacy into two groups (responsive and unresponsive). All patients and 10 controls underwent orbital MRI examination at baseline. No significant difference was seen in baseline clinical characteristics between the two GO groups. The values of exophthalmos were higher in both GO groups than in the control and were higher in the responsive group versus the unresponsive group. Compared to the unresponsive group, the responsive group had a thicker inferior rectus as well as thinner orbital fat. The inferior rectus/fat ratio was significantly higher in the responsive group versus the unresponsive group. Multivariate logistic regression analysis showed that the exophthalmos value and inferior rectus/fat ratio were significantly associated with the response to glucocorticoid (GC). ROC analysis revealed that the cut-off points of the inferior rectus/fat ratio combined with the exophthalmos value to indicate efficacy were 1.42 and 20.78. For moderate-severe GO patients with CAS > 3, the combined inferior rectus/fat ratio and exophthalmos value in MRI may be a valuable indicator to predict the response to GC therapy.
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影响因子：
5.8
作者：
Bartalena, L.;Krassas, G. E.;von Arx, G.
通讯作者：
von Arx, G.
影响因子：
6.6
作者：
Regensburg, Noortje I.;Wiersinga, Wilmar M.;Mourits, Maarten P.
通讯作者：
Mourits, Maarten P.
影响因子：
4.1
作者：
MOURITS, MP;KOORNNEEF, L;VANDERGAAG, R
通讯作者：
VANDERGAAG, R
影响因子：
13.7
作者：
Regensburg, Noortje I.;Wiersinga, Wilmar M.;Mourits, Maarten P.
通讯作者：
Mourits, Maarten P.
DOI：
10.3109/01676830.2015.1099689
发表时间：
2016-01-01
期刊：
ORBIT-AN INTERNATIONAL JOURNAL ON ORBITAL DISORDERS AND FACIAL RECONSTRUCTIVE SURGERY
影响因子：
--
作者：
Thornton, Ivey L.;Clark, Jeremy;Nunery, William R.
通讯作者：
Nunery, William R.