Altered spontaneous activity in anisometropic amblyopia subjects: revealed by resting-state FMRI.
Altered spontaneous activity in anisometropic amblyopia subjects: revealed by resting-state FMRI.
复制标题
屈光参差性弱视受试者自发活动的改变：静息态功能磁共振成像揭示
DOI：
10.1371/journal.pone.0043373
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Jiang T
中科院分区：
文献类型：
--
作者：
Lin X;Ding K;Liu Y;Yan X;Song S;Jiang T
弱视，也被称为懒惰眼，通常发生在儿童早期，并导致视力不佳或模糊。近期的神经影像学研究发现弱视存在皮质结构/功能异常。然而，直到现在，仍不清楚弱视患者的大脑自发活动是否发生变化。在本研究中，局部一致性（ReHo），一种功能性磁共振成像信号同质性的测量方法，首次被用于研究屈光参差性弱视个体静息态局部大脑自发活动的变化。与年龄和性别匹配的视力正常的受试者相比，屈光参差性弱视受试者在右侧楔前叶、左侧内侧前额叶皮质、左侧额下回以及左侧小脑的大脑自发活动ReHo降低，并且在中央后回和中央前回的双侧联合区、左侧中央旁小叶、左侧颞上回、左侧梭状回、右侧岛叶与壳核联合区以及右侧枕中回发现大脑自发活动ReHo升高。观察到的ReHo降低可能反映了视觉 - 运动处理能力下降，而在躯体感觉皮质、运动区和听觉区ReHo的升高可能表明弱视中的代偿性可塑性。
Amblyopia, also known as lazy eye, usually occurs during early childhood and results in poor or blurred vision. Recent neuroimaging studies have found cortical structural/functional abnormalities in amblyopia. However, until now, it was still not known whether the spontaneous activity of the brain changes in amblyopia subjects. In the present study, regional homogeneity (ReHo), a measure of the homogeneity of functional magnetic resonance imaging signals, was used for the first time to investigate changes in resting-state local spontaneous brain activity in individuals with anisometropic amblyopia. Compared with age- and gender-matched subjects with normal vision, the anisometropic amblyopia subjects showed decreased ReHo of spontaneous brain activity in the right precuneus, the left medial prefrontal cortex, the left inferior frontal gyrus, and the left cerebellum, and increased ReHo of spontaneous brain activity was found in the bilateral conjunction area of the postcentral and precentral gyri, the left paracentral lobule, the left superior temporal gyrus, the left fusiform gyrus, the conjunction area of the right insula, putamen and the right middle occipital gyrus. The observed decreases in ReHo may reflect decreased visuo-motor processing ability, and the increases in ReHo in the somatosensory cortices, the motor areas and the auditory area may indicate compensatory plasticity in amblyopia.
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DOI：
10.1111/j.1460-9568.2009.06650.x
发表时间：
2009-03
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Hess RF;Thompson B;Gole G;Mullen KT
通讯作者：
Mullen KT
影响因子：
4.8
作者：
Burton, H;Sinclair, RJ;McLaren, DG
通讯作者：
McLaren, DG
DOI：
10.3928/0191-3913-20020101-05
发表时间：
2002-01-01
影响因子：
1.2
作者：
Choi, MY;Lee, DS;Yu, YS
通讯作者：
Yu, YS
影响因子：
14.5
作者：
HASHIMOTO, M;OHTSUKA, K
通讯作者：
OHTSUKA, K
影响因子：
3.6
作者：
Fadiga, Luciano;Craighero, Laila
通讯作者：
Craighero, Laila