VITamin D and OmegA-3 TriaL (VITAL) bone health ancillary study: clinical factors associated with trabecular bone score in women and men.
VITamin D and OmegA-3 TriaL (VITAL) bone health ancillary study: clinical factors associated with trabecular bone score in women and men.
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DOI：
10.1007/s00198-018-4633-3
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
LeBoff MS
中科院分区：
文献类型：
--
作者：
Goldman AL;Donlon CM;Cook NR;Manson JE;Buring JE;Copeland T;Yu CY;LeBoff MS
我们调查了TBS是否因性别、种族/民族、体重指数(BMI)和其他临床变量而不同。维生素D和omega-3试验(VITAL)正在确定维生素D3和/或omega-3脂肪酸(FA)补充剂在降低癌症和心血管疾病风险方面的效果。在VITAL：对骨结构/建筑的影响辅助研究中，将调查这些干预措施对骨的影响。在这里，我们研究了临床危险因素与骨健康亚队列中基线的TBS评估的关系，包括672名参与者(369名男性和303名女性)，平均(±SD)年龄63.5±6.0岁；体重指数≤37 kg/m2，2年内未服用双膦酸盐或1年内未服用其他骨活性药物。男性的TBS高于女性(1.311比1.278；p<；0.001)，BMI升高(p<；0.001)、年龄较高(p=0.004)、糖尿病(p=0.008)、使用SSRI(p=0.044)和大量饮酒(p=0.009)的患者TBS较低。有脆性骨折史的趋势(p=0.072)，TBS降低。当按种族/民族、吸烟、跌倒史、复合维生素或咖啡因使用进行分析时，TBS没有变化。女性、年龄、体重指数、≥25 kg/m2、SSRI使用、饮酒和有糖尿病史与TBS降低有关；TBS降低与脆性骨折史有相关趋势。TBS在临床上可能有助于评估超重或肥胖、服用SSRI或糖尿病患者中可能与骨折相关的结构变化。正在进行的后续研究将阐明补充维生素D3和/或FA对TBS和其他骨骼健康措施的影响。在维生素D和omega-3试验(VITAL)的骨健康亚队列中，我们调查了临床变量与TBS基线的相关性。女性、年龄、体重指数、≥25 kg/m2、服用SSRI、高酒精摄入量、有糖尿病史与低TBS有关；低TBS与脆性骨折史有显著相关性。
We investigated whether TBS differs by sex, race/ethnicity, body mass index (BMI), and other clinical variables. The VITamin D and OmegA-3 TriaL (VITAL) is determining effects of vitamin D3 and/or omega-3 fatty acid (FA) supplements in reducing risks of cancer and cardiovascular disease. In the VITAL: Effects on Bone Structure/Architecture ancillary study, effects of these interventions on bone will be investigated. Here we examine the associations of clinical risk factors with TBS assessments at baseline in the bone health subcohort, comprised of 672 participants (369 men and 303 women), mean (±SD) age 63.5±6.0 yrs; BMI ≤ 37 kg/m2, no bisphosphonates within 2 years or other bone active medications within 1 year. TBS was greater in men than women (1.311 vs. 1.278; p<0.001) and lower with elevated BMIs (p<0.001), higher age (p=0.004), diabetes (p=0.008), SSRI use (p=0.044), and high alcohol intake (p=0.009). There was a trend for history of fragility fractures (p=0.072), and lower TBS. TBS did not vary when analyzed by race/ethnicity, smoking, history of falls, multivitamin or caffeine use. Lower TBS was associated with female sex, aging, BMI ≥25 kg/m2, SSRI use, alcohol use and presence of diabetes; there was a trend between lower TBS and history of fragility fractures. TBS may be useful clinically to assess structural changes that may be associated with fractures among patients who are overweight or obese, those on SSRIs or with diabetes. Ongoing follow-up studies will clarify the effects of supplemental vitamin D3 and/or FA’s on TBS and other bone health measures. We investigated the association of clinical variables with TBS at baseline in the bone health subcohort of the VITamin D and OmegA-3 TriaL (VITAL). Lower TBS was associated with female sex, aging, BMI ≥25 kg/m2, SSRI use, high alcohol intake, and presence of diabetes; there was a trend towards significance between lower TBS and history of fragility fractures.
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影响因子：
4.1
作者：
Leslie, W. D.;Aubry-Rozier, B.;Hans, D.
通讯作者：
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影响因子：
5.8
作者：
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影响因子：
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作者：
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通讯作者：
Bliziotes, Michael
影响因子：
2.5
作者：
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通讯作者：
Binkley, Neil
影响因子：
5.8
作者：
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GOLDSMITH, SJ