Effect of Daily Light on c-Fos Expression in the Suprachiasmatic Nucleus under Jet Lag Conditions.
Effect of Daily Light on c-Fos Expression in the Suprachiasmatic Nucleus under Jet Lag Conditions.
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DOI：
10.1267/ahc.18001
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发表时间：
2018-04-27
影响因子：
2.4
通讯作者：
Okamura H
中科院分区：
文献类型：
--
作者：
Chen Y;Yamaguchi Y;Suzuki T;Doi M;Okamura H
时差症状是由于在跨越多个时区旅行时，内部生物钟与外部太阳时间之间的时间不一致造成的。光被认为是生物钟的强烈计时信号。我们通过检测8小时超前时差条件下视交叉上核(SCN)主钟神经元c-Fos的表达，探讨了日光在时差过程中的作用。在WT小鼠中，c-Fos免疫反应在光暗推进(LD)后第一天的1-2小时出现。在第二天和第三天也观察到了这种诱导，尽管它们的水平每天都在减少。相比之下，在V1a-/-V1b-/-小鼠的SCN中，c-Fos的诱导只在第一天才被检测到，即使在8小时的阶段推进后，这些小鼠几乎没有表现出时差症状。这些结果表明，在WT小鼠LD阶段推进后，外界光照对SCN神经元活动的影响持续了3天，提示时差条件下SCN神经元活动变化的持续进行。值得注意的是，在V1a-/-V1b-/-SCN中有限的c-Fos诱导也与突变小鼠在8小时LD阶段推进后SCN时钟的快速重新捕获一致。
Jet-lag symptoms arise from temporal misalignment between the internal circadian clock and external solar time when traveling across multiple time zones. Light is known as a strong timing cue of the circadian clock. We here examined the effect of daily light on the process of jet lag by detecting c-Fos expression in the master clock neurons in the suprachiasmatic nucleus (SCN) under 8-hr phase-advanced jet lag condition. In WT mice, c-Fos-immunoreactivity was found at 1–2 hours on the first day after light/dark (LD) phase-advance. This induction was also observed on the second and third days, although their levels were diminished day by day. In contrast, c-Fos induction in the SCN of V1a–/–V1b–/– mice, which show virtually no jet lag symptoms even after 8-hr phase-advance, was only detected on the first day. These results indicate that external light has affected SCN neuronal activity for 3 days after LD phase-advance in WT mice suggesting the continuous progress of activity change of SCN neurons under jet lag conditions. Noteworthy, limited c-Fos induction in V1a–/–V1b–/– SCN is also consistent with the rapid reentrainment of the SCN clock in mutant mice after 8-hr LD phase-advance.
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DOI：
10.1073/pnas.0808180106
发表时间：
2009-03-17
影响因子：
11.1
作者：
Scheer, Frank A. J. L.;Hilton, Michael F.;Shea, Steven A.
通讯作者：
Shea, Steven A.
影响因子：
16.2
作者：
KORNHAUSER, JM;NELSON, DE;TAKAHASHI, JS
通讯作者：
TAKAHASHI, JS
影响因子：
2.9
作者：
Beaulé, C;Amir, S
通讯作者：
Amir, S
影响因子：
14
作者：
Vargis, Elizabeth;Peterson, Cristen B.;Collier, Charles Patrick
通讯作者：
Collier, Charles Patrick
影响因子：
56.9
作者：
SAGAR, SM;SHARP, FR;CURRAN, T
通讯作者：
CURRAN, T