Occurrence, elimination, enantiomeric distribution and intra-day variations of chiral pharmaceuticals in major wastewater treatment plants in Beijing, China.
Occurrence, elimination, enantiomeric distribution and intra-day variations of chiral pharmaceuticals in major wastewater treatment plants in Beijing, China.
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中国北京主要污水处理厂中手性药物的出现、消除、对映体分布和日内变化。
DOI：
10.1016/j.envpol.2018.04.014
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发表时间：
2018-04
影响因子：
8.9
通讯作者：
Yu Gang
中科院分区：
文献类型：
--
作者：
Duan Lei;Zhang Yizhe;Wang Bin;Deng Shubo;Huang Jun;Wang Yujue;Yu Gang
在中国北京的八个主要污水处理厂中调查了五种手性药物（三种β受体阻滞剂和两种抗抑郁药）的出现、消除、对映体分布和日内变化。结果显示，美托洛尔 (MTP) 和文拉法辛 (VFX) 在五种确定的药物中浓度最高，进水平均浓度分别为 803ngL-1 和 408ngL-1，出水平均浓度分别为 354ngL-1 和 165ngL-1。进一步分析了废水处理过程中它们的去除效率、日内浓度变化和对映体特征。还对这两种手性药物的负载进行了研究，以揭示药物使用模式。 A/A/O+MBR（厌氧/缺氧/好氧+膜生物反应器）联合消毒处理工艺表现出较高的去除效率。在大多数污水处理厂中没有观察到对映选择性或很弱。然而，在采用 A/A/O+MBR 的 WWTP3 中观察到 MTP 的明显对映体分数 (EF) 变化。 MTP 的日内浓度波动小于 VFX。在 WWTP1 出水中观察到对 MTP 进水浓度突然升高的快速响应，但 EF 响应滞后。考虑到水力停留时间 (HRT)，在大多数污水处理厂的 MTP 和 VFX 中也观察到进水和出水的类似每两小时 EF 变化。
The occurrence, eliminations, enantiomeric distribution and intra-day variations of five chiral pharmaceuticals (three beta-blockers and two antidepressants) were investigated in eight major WWTPs in Beijing, China. The results revealed that metoprolol (MTP) and venlafaxine (VFX) were of the highest concentrations among the five determined pharmaceuticals with mean concentrations of 803 ng L−1and 408 ng L−1, respectively in influents, and 354 ng L−1and 165 ng L−1in effluents, respectively. Their removal efficiencies, intra-day concentration changes and enantiomeric profiles during wastewater treatment were further analyzed. Loads of these two chiral pharmaceuticals were also studied to reveal drug use pattern. A/A/O+MBR (anaerobic/anoxic/oxic + membrane bio-reactor) followed by joint disinfection treatment process exhibited the high removal efficiencies. No or weak enantioselectivity was observed in most WWTPs. However, obvious enantiomeric fraction (EF) changing of MTP was observed in WWTP3 employing A/A/O+MBR. Intra-day concentration fluctuations of MTP were smaller than VFX. A quick response to sudden rise influent concentration of MTP was observed in WWTP1 effluent but EF response lagged behind. Similar bihourly EF variations in influents and effluents were also observed in most WWTPs for MTP and VFX in consideration of hydraulic residence time (HRT).
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