Angiotensin II-induced atrial natriuretic factor release in dogs is not related to hemodynamic responses.
Angiotensin II-induced atrial natriuretic factor release in dogs is not related to hemodynamic responses.
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血管紧张素 II 诱导的狗心房钠尿因子释放与血流动力学反应无关。
DOI：
10.1161/01.res.67.3.774
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发表时间：
1990
影响因子：
20.1
通讯作者：
Laragh,JH
中科院分区：
文献类型：
--
作者：
Volpe,M;Atlas,SA;Sosa,RE;Marion,DE;Mueller,FB;Sealey,JE;Laragh,JH
血管紧张素 II (Ang II) 和心房钠尿因子 (ANF) 似乎在调节体液和电解质稳态以及血压方面充当功能拮抗剂。为了进一步明确体内这些激素之间的关系，我们研究了低剂量 Ang II (1-10 ng/kg/min) 对血浆 ANF 水平的影响。我们还评估了 ANF 释放对 ANG II 的肾脏和激素反应的影响。研究是在麻醉和清醒的仪器狗中进行的，在持续盐水负荷和转化酶抑制期间进行。在麻醉犬中，Ang II 显着增加血浆 ANF 水平和 ANF 动静脉差异，而不改变心房压力或血细胞比容。在清醒和麻醉的狗中，ANF 增加与 Ang II 的血压反应无关，并且当 Ang II 被媒介物替代时，在对照组中也没有出现 ANF 增加。血管紧张素II诱导的钠潴留和醛固酮产生的刺激减弱，而血浆ANF变化最大的狗对转化酶抑制或血管紧张素II的反应增强了肾素抑制。这些结果表明，在容量充足的狗中，Ang II 可以独立于心房压力或全身血流动力学的变化而促进 ANF 释放，这表明 Ang II 可能对 ANF 分泌发挥显着的调节作用。结果还显示 ANF 与肾脏和肾上腺对 Ang II 的反应之间存在显着关系，这可能表明内源性 ANF 反过来调节 Ang II 的作用。
Angiotensin II (Ang II) and atrial natriuretic factor (ANF) appear to act as functional antagonists in the regulation of fluid and electrolyte homeostasis and blood pressure. To further define the relations between these hormones in vivo, we investigated the effect of low doses of Ang II (1-10 ng/kg/min) on plasma ANF levels. We also evaluated the influence of ANF release on the renal and hormonal responses to ANG II. Studies were performed in anesthetized and conscious instrumented dogs during sustained saline load and converting enzyme inhibition. In the anesthetized dogs, Ang II significantly increased plasma ANF levels and ANF arteriovenous difference without changing either atrial pressures or hematocrit. In both conscious and anesthetized dogs, ANF increases were not correlated with blood pressure responses to Ang II and did not occur in control groups when Ang II was replaced by vehicle. Ang II-induced sodium retention and stimulation of aldosterone production were attenuated, and renin suppression was enhanced in dogs having the largest changes in plasma ANF in response to converting enzyme inhibition or Ang II. These results demonstrate that in volume-replete dogs Ang II can promote ANF release independently of changes in atrial pressures or systemic hemodynamics, suggesting that Ang II may exert a significant modulatory effect on ANF secretion. The results also show significant relations between ANF and renal and adrenal responses to Ang II, which may suggest that, in turn, endogenous ANF modulates the effects of Ang II.
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心房钠尿因子抑制脱水和出血引起的加压素释放。
影响因子：
4.1
作者：
Samson,WK
通讯作者：
Samson,WK
心房钠尿激素、肾素-醛固酮轴和血压-电解质稳态。
DOI：
10.1056/nejm198511213132106
发表时间：
1985
期刊：
The New England journal of medicine
影响因子：
--
作者：
Laragh,JH
通讯作者：
Laragh,JH
影响因子：
20.1
作者：
BEAN, BL;BROWN, JJ;LEVER, AF
通讯作者：
LEVER, AF
大鼠中通过血管收缩剂或水浸泡释放的心房肽与右心房压力的变化相关。
DOI：
10.1016/0006-291x(85)91226-4
发表时间：
1985
影响因子：
3.1
作者：
Nobuo C. Katsube;David J. Schwartz;Philip Needleman
通讯作者：
Philip Needleman
脑肾素-血管紧张素对心脏心房钠尿因子分泌的中枢控制
影响因子：
8.3
作者：
H. Itoh;Takayuki Yamada;Narito More;S. Shiono;A. Sugawara;Yoshmko Sajto;M. Mukoyama;H. Arai;H. Imura
通讯作者：
H. Imura