Prefrontal/accumbal catecholamine system processes high motivational salience.
Prefrontal/accumbal catecholamine system processes high motivational salience.
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DOI：
10.3389/fnbeh.2012.00031
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发表时间：
2012
影响因子：
3
通讯作者：
Ventura R
中科院分区：
文献类型：
--
作者：
Puglisi-Allegra S;Ventura R
动机显著性调节着目标寻求的强度、所承担的风险以及从轻度到极端所投入的能量。高度激励的经历促进高度持久的记忆。虽然这种现象在正常情况下是适应性的，但具有极高水平的动机显着性的经历可以促进记忆的发展，这些记忆可以长时间侵入性地重新体验，从而导致适应不良的结果。因此，调节动机显著性归因的神经机制对个体和物种的生存以及幸福非常重要。然而，这些神经机制可能涉及异常的动机显着性归因于不同的刺激，导致适应不良的强迫性寻求或回避。我们提供了第一个证据表明，前额叶皮质去甲肾上腺素（NE）的传输是一个必要的条件，动机的显着性归因于高度显着的刺激，通过调节多巴胺（DA）的核丘脑（NAc），大脑区域参与所有的动机行为。此外，我们还发现，只有当非条件刺激（UCS）的显著性高到足以引起持续的CA激活时，前额叶-海马儿茶酚胺（CA）系统才能决定对奖赏和厌恶相关刺激的接近或回避反应，从而证实该系统选择性地处理高度显著事件的动机显著性归因。
Motivational salience regulates the strength of goal seeking, the amount of risk taken, and the energy invested from mild to extreme. Highly motivational experiences promote highly persistent memories. Although this phenomenon is adaptive in normal conditions, experiences with extremely high levels of motivational salience can promote development of memories that can be re-experienced intrusively for long time resulting in maladaptive outcomes. Neural mechanisms mediating motivational salience attribution are, therefore, very important for individual and species survival and for well-being. However, these neural mechanisms could be implicated in attribution of abnormal motivational salience to different stimuli leading to maladaptive compulsive seeking or avoidance. We have offered the first evidence that prefrontal cortical norepinephrine (NE) transmission is a necessary condition for motivational salience attribution to highly salient stimuli, through modulation of dopamine (DA) in the nucleus accumbens (NAc), a brain area involved in all motivated behaviors. Moreover, we have shown that prefrontal-accumbal catecholamine (CA) system determines approach or avoidance responses to both reward- and aversion-related stimuli only when the salience of the unconditioned stimulus (UCS) is high enough to induce sustained CA activation, thus affirming that this system processes motivational salience attribution selectively to highly salient events.
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影响因子：
1.9
作者：
Bardgett, Mark E.;Depenbrock, Melissa;Downs, Nathan;Points, Megan;Green, Leonard
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.0506308103
发表时间：
2006-01-31
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
10.6
作者：
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