Superstructured Biomaterials Formed by Exchange Dynamics and Host-Guest Interactions in Supramolecular Polymers.
Superstructured Biomaterials Formed by Exchange Dynamics and Host-Guest Interactions in Supramolecular Polymers.
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DOI：
10.1002/advs.202004042
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Stupp SI
中科院分区：
文献类型：
--
作者：
Edelbrock AN;Clemons TD;Chin SM;Roan JJW;Bruckner EP;Álvarez Z;Edelbrock JF;Wek KS;Stupp SI
分子的动态可逆组装普遍存在于生命系统的层次结构中，并在细胞功能中起着关键作用。实验室最近的工作报告了在肽两亲物与寡核苷酸和静电互补肽序列缀合的系统中这种超结构的可逆形成。本文报道了一种超分子体系，其中β-环糊精和金刚烷在肽两亲物上的交换动力学和主客体相互作用导致超结构形成。具有成束纳米带的超结构形成产生具有高度多孔结构的机械坚固的水凝胶，其可以被3D打印。多孔超结构材料的功能化与生物信号的结果在一个矩阵具有显着的体外生物活性对神经元，可以用作一个超分子模型，以设计新的生物材料。在这项工作中，交换动力学和主客体之间的相互作用β-环糊精和金刚烷肽两亲物导致分级超结构的形成。这种超结构导致机械坚固，高度多孔的水凝胶适合3D打印。具有生物信号的多孔超结构材料的功能化导致对神经元具有显著体外生物活性的基质。
Dynamic and reversible assembly of molecules is ubiquitous in the hierarchical superstructures of living systems and plays a key role in cellular functions. Recent work from the laboratory reported on the reversible formation of such superstructures in systems of peptide amphiphiles conjugated to oligonucleotides and electrostatically complimentary peptide sequences. Here, a supramolecular system is reported upon where exchange dynamics and host–guest interactions between β‐cyclodextrin and adamantane on peptide amphiphiles lead to superstructure formation. Superstructure formation with bundled nanoribbons generates a mechanically robust hydrogel with a highly porous architecture that can be 3D printed. Functionalization of the porous superstructured material with a biological signal results in a matrix with significant in vitro bioactivity toward neurons that could be used as a supramolecular model to design novel biomaterials. In this work, exchange dynamics and host–guest interactions between β‐cyclodextrin and adamantane on peptide amphiphiles lead to hierarchical superstructure formation. This superstructure leads to mechanically robust, highly porous hydrogels amenable to 3D printing. Functionalization of the porous superstructured material with a biological signal results in a matrix with significant in vitro bioactivity toward neurons.
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影响因子：
16.6
作者：
Boekhoven, Job;Perez, Charles M. Rubert;Sur, Shantanu;Worthy, Amanda;Stupp, Samuel I.
通讯作者：
Stupp, Samuel I.
影响因子：
16.6
作者：
Lanjakornsiripan D;Pior BJ;Kawaguchi D;Furutachi S;Tahara T;Katsuyama Y;Suzuki Y;Fukazawa Y;Gotoh Y
通讯作者：
Gotoh Y
影响因子：
9.7
作者：
Berns EJ;Álvarez Z;Goldberger JE;Boekhoven J;Kessler JA;Kuhn HG;Stupp SI
通讯作者：
Stupp SI
DOI：
10.1002/advs.202004042
发表时间：
2021-04
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
Edelbrock AN;Clemons TD;Chin SM;Roan JJW;Bruckner EP;Álvarez Z;Edelbrock JF;Wek KS;Stupp SI
通讯作者：
Stupp SI
影响因子：
29.4
作者：
Ma, Chunxin;Li, Tiefeng;Xie, Tao
通讯作者：
Xie, Tao