Vasoprotection by dietary supplements and exercise: role of TNFα signaling.
Vasoprotection by dietary supplements and exercise: role of TNFα signaling.
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DOI：
10.1155/2012/972679
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发表时间：
2012
影响因子：
--
通讯作者：
Zhang C
中科院分区：
文献类型：
--
作者：
Zhang H;Zhang C
血管功能障碍是多种心血管疾病的发病机制之一。膳食补充剂，包括鱼油、膳食纤维和各种天然产品，以及运动训练都能发挥血管保护作用。然而，膳食补充剂和体力活动的血管保护作用的机制需要广泛的研究。越来越多的证据表明，炎症细胞因子肿瘤坏死因子-α（TNFα）在大血管和微血管功能失调中起着关键作用。TNFα可诱导血管炎症、单核细胞与内皮细胞粘附、血管氧化应激、细胞凋亡和致动脉粥样硬化反应，并通过NFκB、Sp1、激活蛋白1、JNK、p38、STAT 3等多种信号通路参与血栓形成和凝血的调节。膳食补充剂和运动训练可减少TNFα的产生并改善TNFα介导的血管病变。因此，膳食补充剂和体育锻炼对TNFα产生和TNFα信号传导的抑制作用可能有助于其血管保护特性。
Vascular dysfunction contributes to the pathogenesis of various cardiovascular diseases. Dietary supplements, including fish oil, dietary fibers, and various natural products, and exercise training exert vasoprotective effects. However, the mechanisms underlying the vasoprotective benefits of dietary supplements and physical activity demand extensive investigation. Accumulating evidence suggests that inflammatory cytokine tumor necrosis factor-alpha (TNFα) plays a pivotal role in the dysregulation of macrovascular and microvascular function. TNFα induces vascular inflammation, monocyte adhesion to endothelial cells, vascular oxidative stress, apoptosis, and atherogenic response and participates in the regulation of thrombosis and coagulation through multiple signaling pathways involving NFκB, Sp1, activator protein 1, JNK, p38, STAT3, and so forth. Dietary supplements and exercise training decrease TNFα production and ameliorate TNFα-mediated pathological changes in vasculature. Thus, the inhibitory effects of dietary supplements and physical exercise on TNFα production and TNFα signaling may contribute to their vasoprotective properties.
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