A model of negative emotional contagion between male-female rat dyads: Effects of voluntary exercise on stress-induced behavior and BDNF-TrkB signaling.
A model of negative emotional contagion between male-female rat dyads: Effects of voluntary exercise on stress-induced behavior and BDNF-TrkB signaling.
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DOI：
10.1016/j.physbeh.2020.113286
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发表时间：
2021-05-15
影响因子：
2.9
通讯作者：
Robinson S
中科院分区：
文献类型：
--
作者：
Meade GM;Charron LS;Kilburn LW;Pei Z;Wang HY;Robinson S
情绪传染是指个体之间的情绪状态的共享，并且可以导致与抑郁个体生活在一起的健康人的抑郁行为。在动物模型中已经观察到负面情绪传染，但绝大多数研究都是短期的，与长期的人类关系几乎没有相似之处。因此，本研究的第一个目的是建立一个动物模型的压力引起的负面情绪传染，跨时间和对之间的发展。为了实现这一点，我们测试了一个假设，即久坐不动的雄性大鼠与压力暴露的女性同居五周，将表现出抑郁样表型，这是可观察到的行为和生理措施。此外，从一个全面的文献，描述了以前的运动对压力相关行为的有益影响，我们测试了我们的第二个假设，在男性与压力的女性配对，事先自愿运动会削弱负面情绪传染的影响。我们发现，一对健康的男性和一个有压力的女性会导致情绪传染;男性体重增加较少，是快感缺乏，表现出焦虑样行为，血清脑源性神经营养因子（BDNF）水平较低，海马BDNF刺激的酪氨酸受体激酶B（Trk B）信号转导减少，海马中促炎细胞因子表达增加。在大多数情况下，五周的运动窗口，发生之前对住房几乎没有影响，在非压力配对大鼠，但有部分，但实质性的保护作用，对大鼠与一个强调的女性。具体来说，在压力配对，运动大鼠表现出较少的抑郁样行为，部分保留海马BDNF刺激的TrkB信号，血清BDNF浓度正常化，海马细胞因子和即刻早期基因水平相当于对照组。这些临床前研究结果介绍了一种新的模型之间的男女大鼠的二分体的负面情绪传染和支持的观点，包括运动计划将是有益的人，可能在未来，容易受到负面情绪传染。
Emotional contagion refers to the sharing of emotional states between individuals and can cause depressive behaviors in healthy persons who live with depressed individuals. Negative emotional contagion has been observed in animal models, but the vast majority of studies are short-term and bear little resemblance to long-term human relationships. Thus, the first aim of this study was to establish an animal model of stress-induced negative emotional contagion that develops across time and between pairs. To accomplish this, we tested the hypothesis that sedentary male rats that cohabitate for five weeks with a stress-exposed female will exhibit a depression-like phenotype that is observable on behavioral and physiological measures. In addition, drawing from a comprehensive literature that describes the beneficial effects of prior exercise on stress-related behavior, we tested our second hypothesis that in males that were paired with a stressed female, prior voluntary exercise will blunt the impact of negative emotional contagion. We found that pair housing a healthy male with a stressed female led to emotional contagion; males gained less body weight, were anhedonic, demonstrated heightened anxiety-like behavior, had lower serum brain derived neurotrophic factor (BDNF) levels, had decreased hippocampal BDNF-stimulated tyrosine receptor kinase B (TrkB) signaling and increased pro-inflammatory cytokine expression in the hippocampus. For the most part, the five-week exercise window that occurred prior to pair housing had few effects in non-stress paired rats, but had partial, yet substantial protective effects in rats that were pair-housed with a stressed female. Specifically, among stress-paired, exercised rats showed less depressive-like behavior, had partially preserved hippocampal BDNF-stimulated TrkB signaling, had normalized serum BDNF concentration, and had hippocampal cytokine and immediate early gene levels that were equivalent to controls. These preclinical findings introduce a new model of negative emotional contagion between dyads of male-female rats and support the view that inclusion of exercise programs would be beneficial for persons that may, in the future, be susceptible to negative emotional contagion.
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