Work disability remains a major problem in rheumatoid arthritis in the 2000s: data from 32 countries in the QUEST-RA study.
Work disability remains a major problem in rheumatoid arthritis in the 2000s: data from 32 countries in the QUEST-RA study.
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DOI：
10.1186/ar2951
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发表时间：
2010
影响因子：
4.9
通讯作者：
QUEST-RA
中科院分区：
文献类型：
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作者：
Sokka T;Kautiainen H;Pincus T;Verstappen SM;Aggarwal A;Alten R;Andersone D;Badsha H;Baecklund E;Belmonte M;Craig-Müller J;da Mota LM;Dimic A;Fathi NA;Ferraccioli G;Fukuda W;Géher P;Gogus F;Hajjaj-Hassouni N;Hamoud H;Haugeberg G;Henrohn D;Horslev-Petersen K;Ionescu R;Karateew D;Kuuse R;Laurindo IM;Lazovskis J;Luukkainen R;Mofti A;Murphy E;Nakajima A;Oyoo O;Pandya SC;Pohl C;Predeteanu D;Rexhepi M;Rexhepi S;Sharma B;Shono E;Sibilia J;Sierakowski S;Skopouli FN;Stropuviene S;Toloza S;Valter I;Woolf A;Yamanaka H;QUEST-RA
工作残疾是类风湿性关节炎（RA）的一个主要后果，不仅与传统的疾病活动变量相关，而且与人口、功能、职业和社会变量也更重要。最近的报告表明，使用生物制剂有可能降低工作残疾率，但结论是基于主要来自西方国家的研究得出的替代疾病活动指标。 RA 患者定量标准监测 (QUEST-RA) 跨国数据库包含 32 个国家 86 个地点的 8,039 名患者，其中 16 个国家为高国内生产总值 (GDP)（人均 > 24,000 美元 (USD)）和 16 个低 GDP 国家（<11,000 美元），分析了 RA 发病时和整个过程中的工作和残疾状况，以及高 GDP 与低 GDP 国家中继续工作或停止工作的患者的临床状况根据所有 RA 核心数据集测量。使用描述性统计和回归分析来分析工作残疾状态与 RA 核心数据集变量和指数的关联。在首次出现症状时，86% 的男性（各国范围为 57%-100%）和 64%（19%-87%）的 65 岁以下女性正在工作。超过三分之一 (37%) 的患者报告因 RA 而导致工作丧失能力。在 2000 年代开始出现症状的 1,756 名患者中，2 年继续工作的概率为 80%（95% 置信区间 (CI) 78%-82%），5 年继续工作的概率为 68%（95% CI 65%-71%），高 GDP 和低 GDP 国家的情况相似。继续工作的患者与停止工作的患者在所有临床状态测量和患者自我报告评分方面的临床状态明显更好，高 GDP 和低 GDP 国家的模式相似。然而，在高 GDP 国家停止工作的患者比在低 GDP 国家继续工作的患者具有更好的临床状态。所有亚组中最重要的工作残疾标志是健康评估问卷 (HAQ) 功能残疾评分。在本世纪，类风湿性关节炎患者的工作残疾率仍然很高。在国内生产总值低的国家，人们的残疾率和疾病活动率仍然很高。社会之间的文化和经济差异会影响工作残疾作为 RA 的一项结果指标。
Work disability is a major consequence of rheumatoid arthritis (RA), associated not only with traditional disease activity variables, but also more significantly with demographic, functional, occupational, and societal variables. Recent reports suggest that the use of biologic agents offers potential for reduced work disability rates, but the conclusions are based on surrogate disease activity measures derived from studies primarily from Western countries. The Quantitative Standard Monitoring of Patients with RA (QUEST-RA) multinational database of 8,039 patients in 86 sites in 32 countries, 16 with high gross domestic product (GDP) (>24K US dollars (USD) per capita) and 16 low-GDP countries (<11K USD), was analyzed for work and disability status at onset and over the course of RA and clinical status of patients who continued working or had stopped working in high-GDP versus low-GDP countries according to all RA Core Data Set measures. Associations of work disability status with RA Core Data Set variables and indices were analyzed using descriptive statistics and regression analyses. At the time of first symptoms, 86% of men (range 57%-100% among countries) and 64% (19%-87%) of women <65 years were working. More than one third (37%) of these patients reported subsequent work disability because of RA. Among 1,756 patients whose symptoms had begun during the 2000s, the probabilities of continuing to work were 80% (95% confidence interval (CI) 78%-82%) at 2 years and 68% (95% CI 65%-71%) at 5 years, with similar patterns in high-GDP and low-GDP countries. Patients who continued working versus stopped working had significantly better clinical status for all clinical status measures and patient self-report scores, with similar patterns in high-GDP and low-GDP countries. However, patients who had stopped working in high-GDP countries had better clinical status than patients who continued working in low-GDP countries. The most significant identifier of work disability in all subgroups was Health Assessment Questionnaire (HAQ) functional disability score. Work disability rates remain high among people with RA during this millennium. In low-GDP countries, people remain working with high levels of disability and disease activity. Cultural and economic differences between societies affect work disability as an outcome measure for RA.
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影响因子：
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作者：
Puolakka, K;Kautiainen, H;Leirisalo-Repo, M
通讯作者：
Leirisalo-Repo, M
影响因子：
2.1
作者：
Odegård, S;Finset, A;Uhlig, T
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影响因子：
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通讯作者：
VAUGHN, WK
影响因子：
27.4
作者：
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通讯作者：
Leirisalo-Repo, M
影响因子：
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作者：
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通讯作者：
Hannonen, P