Cholangiocarcinoma.
Cholangiocarcinoma.
复制标题
DOI：
10.1038/s41572-021-00300-2
复制
发表时间：
2021-09-09
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
胆管癌（Cholangiocarcinoma， CCA）是一种高致死率的肝胆系统腺癌，可分为肝内、门周和远端。每个解剖亚型都有不同的遗传畸变、临床表现和治疗方法。在流行地区，由于相关的慢性胆道炎症的致癌作用，肝吸虫感染与CCA相关。在其他地区，CCA可能与胆总管结石、胆石症或原发性硬化性胆管炎引起的慢性胆道炎症有关，但大多数CCA没有明确的病因。使用驱虫药吡喹胍可降低肝吸虫引起CCA的风险，但再次感染是常见的，未来的疫苗接种策略可能更有效。一些CCA患者有可能接受手术治疗，如切除或肝移植。遗传学研究为CCA的发病机制提供了新的见解，两种驱动非吸虫相关肝内CCA发病机制的畸变，成纤维细胞生长因子受体2融合和异柠檬酸脱氢酶功能获得突变，可以作为治疗靶点。CCA是一种高度结缔组织增生的肿瘤，靶向肿瘤免疫微环境可能是一种很有前途的治疗方法。CCA仍然是一种高度致命的疾病，需要进一步的科学和临床见解来改善患者的预后。
Cholangiocarcinoma (CCA) is a highly lethal adenocarcinoma of the hepatobiliary system, which can be classified as intrahepatic, perihilar and distal. Each anatomic subtype has distinct genetic aberrations, clinical presentations and therapeutic approaches. In endemic regions, liver fluke infection is associated with CCA, owing to the oncogenic effect of the associated chronic biliary tract inflammation. In other regions, CCA can be associated with chronic biliary tract inflammation owing to choledocholithiasis, cholelithiasis, or primary sclerosing cholangitis, but most CCAs have no identifiable cause. Administration of the anthelmintic drug praziguantel decreases the risk of CCA from liver flukes, but reinfection is common and future vaccination strategies may be more effective. Some patients with CCA are eligible for potentially curative surgical options, such as resection or liver transplantation. Genetic studies have provided new insights into the pathogenesis of CCA, and two aberrations that drive the pathogenesis of non-fluke-associated intrahepatic CCA, fibroblast growth factor receptor 2 fusions and isocitrate dehydrogenase gain-of-function mutations, can be therapeutically targeted. CCA is a highly desmoplastic cancer and targeting the tumour immune microenvironment might be a promising therapeutic approach. CCA remains a highly lethal disease and further scientific and clinical insights are needed to improve patient outcomes.
登录
查看更多内容
影响因子：
--
作者：
Brivio S;Cadamuro M;Fabris L;Strazzabosco M
通讯作者：
Strazzabosco M
DOI：
10.1093/infdis/jiv291
发表时间：
2015-11-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Chaiyadet S;Sotillo J;Smout M;Cantacessi C;Jones MK;Johnson MS;Turnbull L;Whitchurch CB;Potriquet J;Laohaviroj M;Mulvenna J;Brindley PJ;Bethony JM;Laha T;Sripa B;Loukas A
通讯作者：
Loukas A
DOI：
10.1016/s1470-2045(20)30157-1
发表时间：
2020-06
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Abou-Alfa GK;Macarulla T;Javle MM;Kelley RK;Lubner SJ;Adeva J;Cleary JM;Catenacci DV;Borad MJ;Bridgewater J;Harris WP;Murphy AG;Oh DY;Whisenant J;Lowery MA;Goyal L;Shroff RT;El-Khoueiry AB;Fan B;Wu B;Chamberlain CX;Jiang L;Gliser C;Pandya SS;Valle JW;Zhu AX
通讯作者：
Zhu AX
影响因子：
3.2
作者：
Buettner, Stefan;ten Cate, David W. G.;Koerkamp, Bas Groot
通讯作者：
Koerkamp, Bas Groot
影响因子：
65.1
作者：
Banales, Jesus M.;Cardinale, Vincenzo;Alvaro, Domenico
通讯作者：
Alvaro, Domenico