Right Ventricular Involution: Big Changes in Small Hearts.
Right Ventricular Involution: Big Changes in Small Hearts.
复制标题
右心室复旧：小心脏的大变化。
DOI：
10.1016/j.jss.2019.05.048
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
McKellar,StephenH
中科院分区：
文献类型：
--
作者：
Bowen,MeganE;Selzman,CraigH;McKellar,StephenH
研究背景出生前，胎儿右心室（RV）是体循环的泵，其厚度与左心室（LV）相当。出生后，RV成为低压肺循环的泵，RV腔室延长，但其壁厚不变。我们假设，胎儿RV可能是一个模型的补偿RV肥大，并了解这一过程可能有助于发现治疗策略RV failure.MethodsWe进行了文献综述，并确定相关的文章从1980年到present.ResultsThe以下主题被确定为最相关的右心室复旧：RV的形态学和组织学变化、细胞增殖和终末分化、应激对RV发育的影响、兴奋收缩偶联和变力性反应随时间的变化，结论右心室从体循环向肺循环过渡后，右心室发生了多层次的变化。尽管已发表的文献中部分由于动物模型之间的差异而产生了不同的结果，但文献显示该领域显然需要进行更多的研究。
BackgroundBefore birth, the fetal right ventricle (RV) is the pump for the systemic circulation and is about as thick as the left ventricle (LV). After birth, the RV becomes the pump for the lower pressure pulmonary circulation, and the RV chamber elongates without change in its wall thickness. We hypothesize that the fetal RV may be a model of compensated RV hypertrophy, and understanding this process may aid in discovering therapeutic strategies for RV failure.MethodsWe performed a literature review and identified pertinent articles from 1980 to present.ResultsThe following topics were identified to be most pertinent in right ventricular involution: morphologic and histologic changes of the RV, cellular proliferation and terminal differentiation, the effect of stress on RV development, excitation contraction coupling and inotropic response change over time, and the amount of apoptosis through RV development.ConclusionsThe RV changes on multiple levels after its transition from systemic to pulmonary circulation. Although published literature has variable results due partly from differences between animal models, the literature shows a clear need for more research in the field.
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影响因子：
5
作者：
ClubbJr,FJ;Penney,DG;Bishop,SP
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影响因子：
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作者：
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DOI：
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影响因子：
6
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DOI：
10.1152/ajpheart.1996.271.5.h2183
发表时间：
1996-11
期刊：
The American journal of physiology
影响因子：
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作者：
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通讯作者：
M. Soonpaa;KYUNG KEUN Kim;L. Pajak;M. Franklin;L. Field
影响因子：
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作者：
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通讯作者：
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