A Novel Cytotoxic Physalin from Physalis angulata

A Novel Cytotoxic Physalin from Physalis angulata
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来自酸浆的新型细胞毒性酸浆蛋白

DOI:
10.1177/1934578x1701201016
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发表时间:
2017-10
影响因子:
1.8
通讯作者:
Sun Yi
Sun Yi
中科院分区:
医学4区
文献类型:
--
作者:
Fan Jia Jia;Liu Xia;Zheng Xi Long;Zhao Hai Yu;Xia Huan;Sun Yi

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从角Physalis (Physalis angulata)整株植物中分离出一种新的physalin, 25-羟基异physalin B(1),以及三种megastigmane葡糖苷(2-4)和八种已知的physalins(5-12)。对化合物1的结构进行了光谱分析。所有化合物对MCF-7人乳腺细胞和HepG2人肝癌细胞均表现出细胞毒活性。
Bioassay-guided fractionation from the whole plant of Physalis angulata led to the isolation of a novel physalin, 25-hydroxylisophysalin B (1), together with three megastigmane glucosides (2-4) and eight known physalins (5-12). The structure of compound 1 was elucidated by analysis of spectroscopic data. All of the compounds exhibited cytotoxic activities against MCF-7 human mammary cells and HepG2 human hepatoma cells.
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