UV-induced reduction in Polycomb repression promotes epidermal pigmentation.
UV-induced reduction in Polycomb repression promotes epidermal pigmentation.
复制标题
紫外线诱导的多康布抑制作用促进表皮色素沉着。
DOI：
10.1016/j.devcel.2021.08.006
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发表时间：
2021-09-27
影响因子：
11.8
通讯作者：
Ezhkova E
中科院分区：
文献类型：
--
作者：
Li MY;Flora P;Pu H;Bar C;Silva J;Cohen I;Galbo PM Jr;Liu H;Yu X;Jin J;Koseki H;D'Orazio JA;Zheng D;Ezhkova E
紫外线(UV)辐射是我们的表皮每天暴露在其中的主要环境应激源。为了避免紫外线损伤，表皮干细胞(EPSCs)通过黑素细胞和EPSCs之间的异型相互作用而变得有色，但这种相互作用的分子机制尚不清楚。在这项研究中，我们显示了一种关键的染色质调节因子，多梳复合体的功能，在人和小鼠的表皮中受到紫外线照射的影响。遗传消融小鼠EPSCs中的关键多梳亚单位，模拟紫外线照射时的耗竭，导致表皮黑素细胞数量增加和随后的表皮色素沉着。全基因组转录和染色质研究表明，Polycomb调节紫外线反应基因的表达，并确定II型胶原(COL2A1)是黑素生成和表皮色素形成的关键分泌调节因子。综上所述，我们的发现表明紫外线照射是如何诱导EPSCs中聚梳介导的变化来影响黑素细胞的行为并促进表皮色素沉积的。Li等人。证明低剂量UVB照射会导致表皮中的聚梳状物质水平急剧下降。此外，去除表皮中的Polycomb功能会通过一条不依赖于P53的途径导致表皮色素沉着。他们确定多梳调节蛋白，II型胶原，是黑素生成的关键调节因子。
Ultraviolet (UV) radiation is a prime environmental stressor that our epidermis is exposed to on a daily basis. To avert UV-induced damage, epidermal stem cells (EpSCs) become pigmented via a process of heterotypic interaction between melanocytes and EpSCs, however the molecular mechanisms of this interaction are not well understood. In this study we show that the function of a key chromatin regulator, the Polycomb complex, was reduced upon UV exposure in human and mouse epidermis. Genetic ablation of key Polycomb subunits in murine EpSCs, mimicking depletion upon UV exposure, results in an increased number of epidermal melanocytes and subsequent epidermal pigmentation. Genome-wide transcriptional and chromatin studies show that Polycomb regulates the expression of UV-responsive genes and identify type II collagen (COL2A1) as a critical secreted regulator of melanogenesis and epidermal pigmentation. Altogether, our findings show how UV-exposure induces Polycomb-mediated changes in EpSCs to affect melanocyte behavior and promote epidermal pigmentation. Li et al. demonstrate that low-dose UVB exposure leads to a drastic reduction in Polycomb levels in the epidermis. Furthermore, ablation of Polycomb function in the epidermis results in epidermal pigmentation via a p53-independent pathway. They identify Polycomb-regulated protein, type II collagen, as a critical regulator of melanogenesis.
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DOI：
10.18632/aging.101496
发表时间：
2018-07-18
期刊：
Aging
影响因子：
--
作者：
Cho BA;Yoo SK;Seo JS
通讯作者：
Seo JS
DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
影响因子：
10.5
作者：
Cohen I;Bar C;Liu H;Valdes VJ;Zhao D;Galbo PM Jr;Silva JM;Koseki H;Zheng D;Ezhkova E
通讯作者：
Ezhkova E
影响因子：
64.8
作者：
Chang, Chiung-Ying;Pasolli, H. Amalia;Giannopoulou, Eugenia G.;Guasch, Geraldine;Gronostajski, Richard M.;Elemento, Olivier;Fuchs, Elaine
通讯作者：
Fuchs, Elaine
影响因子：
4.8
作者：
Chung, Heesung;Suh, Eun-Kyung;Oh, Eok-Soo
通讯作者：
Oh, Eok-Soo