Development of manganese-based nanoparticles as contrast probes for magnetic resonance imaging.
Development of manganese-based nanoparticles as contrast probes for magnetic resonance imaging.
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作者：
Zhen Z;Xie J
磁共振成像是临床上最重要的影像检查工具之一。它询问活体中的原子核，以高空间和时间分辨率提供详细的描绘。为了弥补先天的低灵敏度，MRI对比剂探头应运而生并得到了广泛的应用。它们通常是顺磁或超顺磁性材料，通过减少附近质子的弛豫时间来发挥作用。以前，以Gd为基础的T1对比探头占主导地位。然而，最近发现，它们的使用有时与肾源性系统纤维化(NSF)有关，这表明需要寻找替代品。在这些努力中，含锰纳米颗粒引起了极大的关注。通过精心设计，可以得到具有类似R1驰豫系数的纳米锰颗粒。此外，其他功能，如靶向基序、治疗剂或第二成像组件，可以被加载到这些纳米颗粒上，从而产生多功能纳米平台。
MRI is one of the most important imaging tools in clinics. It interrogates nuclei of atoms in a living subject, providing detailed delineation with high spatial and temporal resolutions. To compensate the innate low sensitivity, MRI contrast probes were developed and widely used. These are typically paramagnetic or superparamagnetic materials, functioning by reducing relaxation times of nearby protons. Previously, gadolinium(Gd)-based T1 contrast probes were dominantly used. However, it was found recently that their uses are occasionally associated with nephrogenic system fibrosis (NSF), which suggests a need of finding alternatives. Among the efforts, manganese-containing nanoparticles have attracted much attention. By careful engineering, manganese nanoparticles with comparable r1 relaxivities can be yielded. Moreover, other functionalities, be a targeting motif, a therapeutic agent or a second imaging component, can be loaded onto these nanoparticles, resulting in multifunctional nanoplatforms.
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影响因子：
5.7
作者：
Aoki, I;Wu, YJL;Koretsky, AP
通讯作者：
Koretsky, AP
影响因子：
14
作者：
Huang, Chih-Chia;Khu, Ngee-Huat;Yeh, Chen-Sheng
通讯作者：
Yeh, Chen-Sheng
影响因子：
9.5
作者：
Baek, Myung Ju;Park, Ja Young;Lee, Gang Ho
通讯作者：
Lee, Gang Ho
DOI：
10.1196/annals.1306.009
发表时间：
2004-01-01
期刊：
REDOX-ACTIVE METALS IN NEUROLOGICAL DISORDERS
影响因子：
--
作者：
Dobson, AW;Erikson, KM;Aschner, M
通讯作者：
Aschner, M
影响因子：
1.9
作者：
Idee, Jean-Marc;Port, Marc;Corot, Claire
通讯作者：
Corot, Claire