Modulation of functional network properties in major depressive disorder following electroconvulsive therapy (ECT): a resting-state EEG analysis.
Modulation of functional network properties in major depressive disorder following electroconvulsive therapy (ECT): a resting-state EEG analysis.
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电惊厥治疗（ECT）后重性抑郁症功能网络特性的调节：静息状态脑电图分析。
DOI：
10.1038/s41598-020-74103-y
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发表时间：
2020-10-13
影响因子：
4.6
通讯作者：
Daskalakis ZJ
中科院分区：
文献类型：
--
作者：
Hill AT;Hadas I;Zomorrodi R;Voineskos D;Farzan F;Fitzgerald PB;Blumberger DM;Daskalakis ZJ
电休克治疗（ECT）是治疗难治性抑郁症（MDD）的一种高效的神经调节干预。然而，目前对其神经生理学效应的理解仍然不完整。在本研究中，我们利用静息态脑电图（RS-EEG），探讨功能连接，网络拓扑结构和频谱功率的变化引起的急性开放标签过程中的ECT在一个队列的23例难治性MDD患者。RS-EEG在ECT开始前记录，并在每位患者最后一次治疗后48小时内再次记录。我们的研究结果表明，ECT能够增强连接在较低的（三角洲和θ）频带内的子网络主要局限于额中央通道，而相反，更广泛的子网络减少连接出现在更快的（α和β）带治疗后。基于图形的拓扑分析揭示了ECT后功能隔离（聚类系数），整合（特征路径长度）和小世界架构的变化。最后，观察到δ和θ谱功率的治疗后增强，这表明与接受的ECT会话次数呈正相关。总的来说，我们的研究结果表明，RS-EEG可以提供一个敏感的测量ECT后的动态神经活动，并强调基于网络的分析作为一个有前途的途径，进一步机制的理解惊厥治疗的影响。
Electroconvulsive therapy (ECT) is a highly effective neuromodulatory intervention for treatment-resistant major depressive disorder (MDD). Presently, however, understanding of its neurophysiological effects remains incomplete. In the present study, we utilised resting-state electroencephalography (RS-EEG) to explore changes in functional connectivity, network topology, and spectral power elicited by an acute open-label course of ECT in a cohort of 23 patients with treatment-resistant MDD. RS-EEG was recorded prior to commencement of ECT and again within 48 h following each patient’s final treatment session. Our results show that ECT was able to enhance connectivity within lower (delta and theta) frequency bands across subnetworks largely confined to fronto-central channels, while, conversely, more widespread subnetworks of reduced connectivity emerged within faster (alpha and beta) bands following treatment. Graph-based topological analyses revealed changes in measures of functional segregation (clustering coefficient), integration (characteristic path length), and small-world architecture following ECT. Finally, post-treatment enhancement of delta and theta spectral power was observed, which showed a positive association with the number of ECT sessions received. Overall, our findings indicate that RS-EEG can provide a sensitive measure of dynamic neural activity following ECT and highlight network-based analyses as a promising avenue for furthering mechanistic understanding of the effects of convulsive therapies.
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影响因子：
3.7
作者：
Humphries MD;Gurney K
通讯作者：
Gurney K
影响因子：
7.2
作者：
Ajilore, Olusola;Lamar, Melissa;Leow, Alex;Zhang, Aifeng;Yang, Shaolin;Kumar, Anand
通讯作者：
Kumar, Anand
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
14.5
作者：
Farzan, Faranak;Atluri, Sravya;Daskalakis, Zafiris J.
通讯作者：
Daskalakis, Zafiris J.
影响因子：
1.9
作者：
ABRAMS, R;VOLAVKA, J;SCHRIFT, M
通讯作者：
SCHRIFT, M