Graph theory analysis of cortical-subcortical networks in late-life depression.
Graph theory analysis of cortical-subcortical networks in late-life depression.
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DOI：
10.1016/j.jagp.2013.03.005
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发表时间：
2014-02
影响因子：
7.2
通讯作者：
Kumar, Anand
中科院分区：
文献类型：
--
作者：
Ajilore, Olusola;Lamar, Melissa;Leow, Alex;Zhang, Aifeng;Yang, Shaolin;Kumar, Anand
晚期重性抑郁症（LLD）的特征是独特的流行病学和心理社会因素，以及与特定神经解剖学差异相关的医学共病。本研究的目的是使用区域间的相关性的皮质和皮质下的体积检查皮质-皮质下的结构网络属性与LLD相比，健康的对照组。横断面神经影像学研究一般社区我们招募了73名健康老年对照组和53名LLD志愿者。在控制年龄、性别和颅内体积后，使用脑连接性分析仪（www.brain-connectivity-toolbox.net）通过关联区域体积生成脑网络连接性测量。整体网络强度的结果显示，与健康的老年人网络相比，LLD网络的正相关和负相关权重的关联程度更大。LLD网络也显示出与健康对照受试者相比大脑网络结构的改变。与健康老年对照受试者相比，LLD网络也更容易受到有针对性的攻击，并且当控制白色物质改变时，这种脆弱性减弱。总体而言，这项研究表明，皮质-皮质下网络的性质改变LLD，并可能反映了潜在的神经解剖脆弱性的障碍。
Late-life major depression (LLD) is characterized by distinct epidemiological and psychosocial factors, as well as medical co-morbidities that are associated with specific neuroanatomical differences. The purpose of this study was to use interregional correlations of cortical and subcortical volumes to examine cortical-subcortical structural network properties in subjects with LLD compared to healthy comparison subjects. Cross-sectional neuroimaging study General community We recruited 73 healthy elderly comparison subjects and 53 subjects with LLD who volunteered in response to advertisements. Brain network connectivity measures were generated by correlating regional volumes after controlling for age, gender, and intracranial volume using the Brain Connectivity Toolbox (www.brain-connectivity-toolbox.net). Results for overall network strength revealed that LLD networks showed a greater magnitude of associations for both positive and negative correlation weights compared to healthy elderly networks. LLD networks also demonstrated alterations in brain network structure when compared to healthy comparison subjects. LLD networks were also more vulnerable to targeted attacks compared to healthy elderly comparison subjects and this vulnerability was attenuated when controlling for white matter alterations. Overall, this study demonstrates that cortical-subcortical network properties are altered in LLD and may reflect the underlying neuroanatomical vulnerabilities of the disorder.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
2.3
作者：
Dalby, Rikke Beese;Frandsen, Jesper;Ostergaard, Leif
通讯作者：
Ostergaard, Leif
影响因子：
--
作者：
Kumar, Anand;Gupta, Rakesh;Hellemann, Gerhard
通讯作者：
Hellemann, Gerhard
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y