Importance of Both Innate Immunity and Acquired Immunity for Rapid Expulsion of S. venezuelensis.
Importance of Both Innate Immunity and Acquired Immunity for Rapid Expulsion of S. venezuelensis.
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DOI：
10.3389/fimmu.2014.00118
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发表时间：
2014
影响因子：
7.3
通讯作者：
Nakanishi K
中科院分区：
文献类型：
--
作者：
Yasuda K;Matsumoto M;Nakanishi K
在本综述的第一部分中，我们描述了内源性IL-33对ILC 2和嗜酸性粒细胞积累的相关作用，即使在Rag 2 −/−小鼠的肺部。II型肺泡上皮（ATII）细胞在其细胞核中表达IL-33，并且用委内瑞拉圆线虫感染通过增加ATII细胞的数量（可能通过几丁质的作用）诱导IL-33的产生。来自ATII细胞的IL-33诱导ILC 2增殖，同时激活它们以产生IL-5和IL-13，其组合诱导肺嗜酸性粒细胞炎症，帮助排出肺中的感染蠕虫。在第二部分中，我们表明，尽管AID-/-小鼠在感染S.委内瑞拉沙门氏菌，他们需要过继转移的免疫血清从S。venezuelensis感染的小鼠获得迅速驱逐S.委内瑞拉。因此，肠道线虫感染诱导各种Th 2免疫应答（例如，Th 2细胞、ILC 2、杯状细胞增生、肠肥大细胞增多症、平滑肌细胞收缩、局部和全身嗜酸性粒细胞增多症以及高血清IgE和IgG 1水平）。然而，并非所有这些都是快速驱逐肠道线虫所必需的。相反，本质上需要Th 2免疫反应的一些组合。
In the first part of this review, we described the relevant roles of endogenous IL-33 for accumulation of ILC2 and eosinophils even in the lungs of Rag2−/− mice. Type II alveolar epithelial (ATII) cells express IL-33 in their nucleus and infection with Strongyloides venezuelensis induces IL-33 production by increasing the number of ATII cells possibly by the action of chitin. IL-33 from ATII cells induces ILC2 proliferation and at the same time activates them to produce IL-5 and IL-13, which in combination induce lung eosinophilic inflammation, aiding to expel infected worms in the lungs. In the second part, we showed that, although AID−/− mice normally develop Th2 cells and intestinal mastocytosis after infection with S. venezuelensis, they need adoptive transfers of immune sera from S. venezuelensis infected mice to obtain the capacity to promptly expel S. venezuelensis. Thus, intestinal nematode infection induces various Th2 immune responses (e.g., Th2 cell, ILC2, goblet cell hyperplasia, intestinal mastocytosis, smooth muscle cell contraction, local and systemic eosinophilia, and high serum level of IgE and IgG1). However, all of them are not necessary for rapid expulsion of intestinal nematodes. Instead, some combinations of Th2 immune responses are essentially required.
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DOI：
10.1073/pnas.0812690106
发表时间：
2009-06-02
影响因子：
11.1
作者：
Cayrol, Corinne;Girard, Jean-Philippe
通讯作者：
Girard, Jean-Philippe
影响因子：
3.2
作者：
El-Malky MA;Maruyama H;Al-Harthi SA;El-Beshbishi SN;Ohta N
通讯作者：
Ohta N
影响因子：
2.1
作者：
Brigandi, RA;Rotman, HL;Abraham, D
通讯作者：
Abraham, D
影响因子：
3.1
作者：
Onah, DN;Uchiyama, F;Nawa, Y
通讯作者：
Nawa, Y
DOI：
10.1016/j.jaci.2011.10.036
发表时间：
2012-01
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Kim HY;Chang YJ;Subramanian S;Lee HH;Albacker LA;Matangkasombut P;Savage PB;McKenzie AN;Smith DE;Rottman JB;DeKruyff RH;Umetsu DT
通讯作者：
Umetsu DT