Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen.
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen.
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DOI：
10.1084/jem.20050855
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发表时间：
2005-11-21
期刊：
影响因子：
--
通讯作者：
Abbas AK
中科院分区：
文献类型：
--
作者：
Knoechel B;Lohr J;Kahn E;Bluestone JA;Abbas AK
将幼稚抗原特异性CD 4 + T细胞转移到表达内源性抗原作为全身性分泌蛋白的淋巴细胞减少小鼠中，导致类似移植物抗宿主病的严重自身免疫。对这种内源性抗原有反应的T细胞发育成引起疾病的效应细胞。从这种疾病中恢复与外周中FoxP 3 + CD 25+调节细胞的后续生成相关。致病性效应细胞和保护性调节细胞在活化后从相同的抗原特异性T细胞群体发育，并且它们的产生可以平行或顺序发生。白细胞介素（IL）-2在这种全身性T细胞反应中起双重作用。在不存在IL-2的情况下，由于T细胞效应功能降低，急性疾病是轻度的，但慢性和进行性疾病发展较晚，并且与外周中不能产生FoxP 3+调节性T（T reg）细胞有关。因此，外周T细胞对系统性抗原的反应经历效应细胞介导的病理学阶段，随后是T reg细胞介导的恢复，并且两者都需要生长因子IL-2。
Transfer of naive antigen-specific CD4+ T cells into lymphopenic mice that express an endogenous antigen as a systemic, secreted protein results in severe autoimmunity resembling graft-versus-host disease. T cells that respond to this endogenous antigen develop into effector cells that cause the disease. Recovery from this disease is associated with the subsequent generation of FoxP3+CD25+ regulatory cells in the periphery. Both pathogenic effector cells and protective regulatory cells develop from the same antigen-specific T cell population after activation, and their generation may occur in parallel or sequentially. Interleukin (IL)-2 plays a dual role in this systemic T cell reaction. In the absence of IL-2, the acute disease is mild because of reduced T cell effector function, but a chronic and progressive disease develops late and is associated with a failure to generate FoxP3+ regulatory T (T reg) cells in the periphery. Thus, a peripheral T cell reaction to a systemic antigen goes through a phase of effector cell–mediated pathology followed by T reg cell–mediated recovery, and both require the growth factor IL-2.
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影响因子：
15.3
作者：
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通讯作者：
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影响因子：
13.6
作者：
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32.4
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通讯作者：
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作者：
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影响因子：
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作者：
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通讯作者：
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