Overweight and prognosis in triple-negative breast cancer patients: a systematic review and meta-analysis.
Overweight and prognosis in triple-negative breast cancer patients: a systematic review and meta-analysis.
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DOI：
10.1038/s41523-021-00325-6
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发表时间：
2021-09-10
影响因子：
5.9
通讯作者：
Borgquist S
中科院分区：
文献类型：
--
作者：
Harborg S;Zachariae R;Olsen J;Johannsen M;Cronin-Fenton D;Bøggild H;Borgquist S
我们进行了一项系统回顾和荟萃分析，调查超重与三阴性乳腺癌（TNBC）患者结局之间的关系。我们使用不同的检索词三阴性乳腺癌（人群）、超重和/或肥胖（暴露）和预后（结局）检索PubMed和Embase。根据世界卫生组织定义超重的指南，我们纳入了纵向观察研究，这些研究在我们的分析中使用了生存统计和风险比（HR）。纳入的研究测量了TNBC诊断时的体重指数，并报告了无病生存期和/或总生存期。研究质量采用Newcastle-Ottawa量表进行评估，研究数据采用流行病学观察性研究的荟萃分析（MOOSE）检查表提取，由两位作者独立进行。随机效应模型用于联合收割机组合效应量（HR），并对结果进行评估和调整可能的出版偏倚。纳入了8，944例TNBC患者的13项研究。荟萃分析显示，与正常体重相比，超重与较短的无病生存期（HR = 1.26; 95%CI：1.09-1.46）和较短的总生存期（HR = 1.29; 95%CI：1.11c1.51）相关。此外，我们的贝叶斯荟萃分析表明，超重个体的无病生存期和总生存期分别较短的可能性高7.4倍和9.9倍。总之，现有数据表明，超重与TNBC患者的无病生存期和总生存期较短相关。由于可能存在发表偏倚，应谨慎解释结果。
We conducted a systematic review and meta-analysis investigating the association between overweight and outcome in triple-negative breast cancer (TNBC) patients. We searched PubMed and Embase using variations of the search terms triple-negative breast cancer (population), overweight and/or obesity (exposure), and prognosis (outcome). Based on the World Health Organization guidelines for defining overweight, we included longitudinal observational studies, which utilized survival statistics with hazard ratios (HRs) in our analysis. The included studies measured body mass index at the time of diagnosis of TNBC and reported disease-free survival and/or overall survival. Study quality was assessed with the Newcastle-Ottawa Scale and study data were extracted using the Meta-analysis of Observational Studies in Epidemiology (MOOSE) checklist, independently by two authors. Random-effects models were used to combine the effect sizes (HRs), and the results were evaluated and adjusted for possible publication bias. Thirteen studies of 8,944 TNBC patients were included. The meta-analysis showed that overweight was associated with both shorter disease-free survival (HR = 1.26; 95%CI: 1.09–1.46) and shorter overall survival (HR = 1.29; 95%CI: 1.11c1.51) compared to normal-weight. Additionally, our Bayesian meta-analyses suggest that overweight individuals are 7.4 and 9.9 times more likely to have shorter disease-free survival and overall survival, respectively. In conclusion, the available data suggest that overweight is associated with shorter disease-free and overall survival among TNBC patients. The results should be interpreted with caution due to possible publication bias.
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DOI：
10.1093/annonc/mdu042
发表时间：
2014-10
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Chan DSM;Vieira AR;Aune D;Bandera EV;Greenwood DC;McTiernan A;Navarro Rosenblatt D;Thune I;Vieira R;Norat T
通讯作者：
Norat T
影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
3.1
作者：
Dawood, Shaheenah;Lei, Xiudong;Gonzalez-Angulo, Ana M.
通讯作者：
Gonzalez-Angulo, Ana M.
影响因子：
4.5
作者：
French, Simone A.;Tangney, Christy C.;Appelhans, Bradley M.
通讯作者：
Appelhans, Bradley M.
影响因子：
39.2
作者：
Goodman, SN
通讯作者：
Goodman, SN