Pharmacological inactivation does not support a unique causal role for intraparietal sulcus in the discrimination of visual number.
Pharmacological inactivation does not support a unique causal role for intraparietal sulcus in the discrimination of visual number.
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DOI：
10.1371/journal.pone.0188820
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Platt ML
中科院分区：
文献类型：
--
作者：
DeWind NK;Peng J;Luo A;Brannon EM;Platt ML
“数感”描述了一种不用计算就能量化的直觉能力。非人类灵长类动物的单神经元记录和人类的功能成像表明，顶内沟是一个重要的神经解剖学位点的数值估计。其他调查线索涉及IPS的许多其他功能，包括注意力和决策。在这里，我们提供了一个直接的测试是否IPS具有功能特异性的数量判断。我们使用蝇蕈醇可逆地和独立的腹侧和外侧顶内区在两只猴子进行数字识别任务和颜色识别任务，大致平衡的困难。失活的任何一个领域造成平行的障碍，在这两个任务，并没有证据表明，在数字处理的选择性赤字。这些研究结果不支持IPS在数字歧视中的因果作用，除非它在颜色歧视中也有作用。我们讨论了我们的研究结果，在光的IPS功能的几种替代假设，包括定向反应的作用，一般的认知作用的注意力和决策过程中，更具体的作用，包括数量和颜色的判断顺序比较。
The “number sense” describes the intuitive ability to quantify without counting. Single neuron recordings in non-human primates and functional imaging in humans suggest the intraparietal sulcus is an important neuroanatomical locus of numerical estimation. Other lines of inquiry implicate the IPS in numerous other functions, including attention and decision making. Here we provide a direct test of whether IPS has functional specificity for numerosity judgments. We used muscimol to reversibly and independently inactivate the ventral and lateral intraparietal areas in two monkeys performing a numerical discrimination task and a color discrimination task, roughly equilibrated for difficulty. Inactivation of either area caused parallel impairments in both tasks and no evidence of a selective deficit in numerical processing. These findings do not support a causal role for the IPS in numerical discrimination, except insofar as it also has a role in the discrimination of color. We discuss our findings in light of several alternative hypotheses of IPS function, including a role in orienting responses, a general cognitive role in attention and decision making processes and a more specific role in ordinal comparison that encompasses both number and color judgments.
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