Miniaturized neural system for chronic, local intracerebral drug delivery.
Miniaturized neural system for chronic, local intracerebral drug delivery.
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DOI：
10.1126/scitranslmed.aan2742
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发表时间：
2018-01-24
影响因子：
17.1
通讯作者：
Langer R
中科院分区：
文献类型：
--
作者：
Dagdeviren C;Ramadi KB;Joe P;Spencer K;Schwerdt HN;Shimazu H;Delcasso S;Amemori KI;Nunez-Lopez C;Graybiel AM;Cima MJ;Langer R
神经退行性疾病药物治疗的最新进展扩大了改善患者衰弱症状的机会。然而，现有的药物治疗通常依赖于全身给药，这导致药物分布广泛，从而增加了毒性风险。鉴于许多关键神经回路具有亚立方毫米体积和细胞特异性特征，以最小的扩散和泄漏将小体积药物施用到受影响的脑区域是必不可少的。我们报告了一种可植入的，远程可控的，小型化的神经药物输送系统，允许动态调整治疗与精确的空间精度的发展。我们证明，该装置可以化学调节局部神经元活动的小型（啮齿动物）和大型（非人类灵长类动物）动物模型，同时允许记录的神经活动，使反馈控制。
Recent advances in medications for neurodegenerative disorders are expanding opportunities for improving the debilitating symptoms suffered by patients. Existing pharmacologic treatments, however, often rely on systemic drug administration, which result in broad drug distribution and consequent increased risk for toxicity. Given that many key neural circuitries have sub-cubic millimeter volumes and cell-specific characteristics, small-volume drug administration into affected brain areas with minimal diffusion and leakage is essential. We report the development of an implantable, remotely controllable, miniaturized neural drug delivery system permitting dynamic adjustment of therapy with pinpoint spatial accuracy. We demonstrate that this device can chemically modulate local neuronal activity in small (rodent) and large (nonhuman primate) animal models, while simultaneously allowing the recording of neural activity to enable feedback control.
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影响因子：
11.2
作者：
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DOI：
10.1073/pnas.1517629112
发表时间：
2015-11-03
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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作者：
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