Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England.
Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England.
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DOI：
10.1136/bmj.n628
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发表时间：
2021-03-18
期刊：
影响因子：
--
通讯作者：
Tomlinson LA
中科院分区：
文献类型：
--
作者：
Forbes H;Morton CE;Bacon S;McDonald HI;Minassian C;Brown JP;Rentsch CT;Mathur R;Schultze A;DeVito NJ;MacKenna B;Hulme WJ;Croker R;Walker AJ;Williamson EJ;Bates C;Mehrkar A;Curtis HJ;Evans D;Wing K;Inglesby P;Drysdale H;Wong AYS;Cockburn J;McManus R;Parry J;Hester F;Harper S;Douglas IJ;Smeeth L;Evans SJW;Bhaskaran K;Eggo RM;Goldacre B;Tomlinson LA
目的：研究在英国疫情的前两波期间，有儿童和没有儿童的成年人感染严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)的风险和冠状病毒疾病2019年的结局(新冠肺炎)是否存在差异。以人口为基础的队列研究，代表英国国民健康保险制度。第一波(2020年2月1日至8月31日)和第二波(2020年9月1日至12月18日)期间英国的初级保健数据和假名关联的医院和重症监护入院和死亡记录。两组成年人(18岁及以上)分别于2020年2月1日和2020年9月1日在全科诊所登记。调整了因家庭中有儿童而感染SARS-CoV-2、与新冠肺炎有关的入院或重症监护、或死于新冠肺炎的风险比。在9名65岁及以下的 334 392名成年人中，在第一波调查中，与儿童同住与录得的非典型肺炎冠状病毒2型感染、入院或重症监护病房、或死于新冠肺炎的风险并无显著关系。在第二波中，在65岁及以下的成年人中，与任何年龄的儿童同住与记录的SARS-CoV-2感染的风险增加(与0-11岁的儿童生活的风险比1.06(95%可信区间1.05-1.08)；与12-18岁的儿童生活的风险比1.22(1.20-1.24)；与0-11岁的儿童生活的与新冠肺炎相关的住院风险(1.18(1.06-1.31)；1.26(1.12至1.40)，用于与12-18岁的儿童生活)。在这两种情况下，与0-11岁的儿童生活在一起会降低死于新冠肺炎和非新冠肺炎原因的风险；与任何年龄的儿童生活在一起也会降低死于非新冠肺炎原因的风险。对于65岁及以下的成年人，在第二波中，与0-11岁的儿童生活在一起与感染SARS-CoV-2的绝对风险增加有关，每10 000人中有40-60人感染SARS-CoV-2，从810人增加到850到870人，住院人数从160人增加到161到165人，每10 000人中有1到5人住院。与12-18岁儿童生活在一起与SARS-CoV-2感染人数每万 增加160-190人和住院人数每10 000增加2-6人有关。与第一波相比，有证据表明，在第二波中，与儿童一起生活的成年人中报告的SARS-CoV-2感染风险和新冠肺炎预后增加。然而，这并没有转化为新冠肺炎死亡风险的实质性增加，风险的绝对增加也很小。
To investigate whether risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and outcomes of coronavirus disease 2019 (covid-19) differed between adults living with and without children during the first two waves of the UK pandemic. Population based cohort study, on behalf of NHS England. Primary care data and pseudonymously linked hospital and intensive care admissions and death records from England, during wave 1 (1 February to 31 August 2020) and wave 2 (1 September to 18 December 2020). Two cohorts of adults (18 years and over) registered at a general practice on 1 February 2020 and 1 September 2020. Adjusted hazard ratios for SARS-CoV-2 infection, covid-19 related admission to hospital or intensive care, or death from covid-19, by presence of children in the household. Among 9 334 392adults aged 65 years and under, during wave 1, living with children was not associated with materially increased risks of recorded SARS-CoV-2 infection, covid-19 related hospital or intensive care admission, or death from covid-19. In wave 2, among adults aged 65 years and under, living with children of any age was associated with an increased risk of recorded SARS-CoV-2 infection (hazard ratio 1.06 (95% confidence interval 1.05 to 1.08) for living with children aged 0-11 years; 1.22 (1.20 to 1.24) for living with children aged 12-18 years) and covid-19 related hospital admission (1.18 (1.06 to 1.31) for living with children aged 0-11; 1.26 (1.12 to 1.40) for living with children aged 12-18). Living with children aged 0-11 was associated with reduced risk of death from both covid-19 and non-covid-19 causes in both waves; living with children of any age was also associated with lower risk of dying from non-covid-19 causes. For adults 65 years and under during wave 2, living with children aged 0-11 years was associated with an increased absolute risk of having SARS-CoV-2 infection recorded of 40-60 per 10 000 people, from 810 to between 850 and 870, and an increase in the number of hospital admissions of 1-5 per 10 000 people, from 160 to between 161 and 165. Living with children aged 12-18 years was associated with an increase of 160-190 per 10 000 in the number of SARS-CoV-2 infections and an increase of 2-6 per 10 000 in the number of hospital admissions. In contrast to wave 1, evidence existed of increased risk of reported SARS-CoV-2 infection and covid-19 outcomes among adults living with children during wave 2. However, this did not translate into a materially increased risk of covid-19 mortality, and absolute increases in risk were small.
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影响因子：
13.6
作者：
Jaffe, Dena H.;Neumark, Yehuda D.;Manor, Orly
通讯作者：
Manor, Orly
影响因子：
4.6
作者：
Portela, Miguel;Schweinzer, Paul
通讯作者：
Schweinzer, Paul
影响因子：
6.3
作者：
Modig, K.;Talback, M.;Ahlbom, A.
通讯作者：
Ahlbom, A.
DOI：
10.1016/s0140-6736(03)12162-9
发表时间：
2003-01-04
期刊：
Lancet (London, England)
影响因子：
--
作者：
Heikkinen T;Järvinen A
通讯作者：
Järvinen A
与传染病的传播相关的社会接触和混合模式。
影响因子：
15.8
作者：
Mossong, Joeel;Hens, Niel;Jit, Mark;Beutels, Philippe;Auranen, Kari;Mikolajczyk, Rafael;Massari, Marco;Salmaso, Stefania;Tomba, Gianpaolo Scalia;Wallinga, Jacco;Heijne, Janneke;Sadkowska-Todys, Malgorzata;Rosinska, Magdalena;Edmunds, W. John
通讯作者：
Edmunds, W. John