Immune Trait Shifts in Association With Tobacco Smoking: A Study in Healthy Women.
Immune Trait Shifts in Association With Tobacco Smoking: A Study in Healthy Women.
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DOI：
10.3389/fimmu.2021.637974
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发表时间：
2021
影响因子：
7.3
通讯作者：
Visconti A
中科院分区：
文献类型：
--
作者：
Piaggeschi G;Rolla S;Rossi N;Brusa D;Naccarati A;Couvreur S;Spector TD;Roederer M;Mangino M;Cordero F;Falchi M;Visconti A
已知吸烟会影响主要免疫细胞群的循环水平，但其对特定免疫细胞亚群的影响仍知之甚少。在这里，使用来自223名健康女性（25名当前吸烟者和198名从未吸烟者）的高分辨率数据，我们研究了吸烟状况与35，651种免疫特征捕获免疫细胞亚群频率之间的关联。我们的研究结果证实，主动吸烟与表达CD25活化标志物的循环CD8+ T细胞的频率增加有关。此外，我们确定了吸烟状态与CD8+ CD25+记忆T细胞、表达CCR4趋化因子受体的CD8+记忆T细胞和CD4+CD8+（双阳性）CD25+ T细胞的相对丰度之间的新关联。我们还观察到，在目前的吸烟者中，表达CD38活化标志物的CD4+ T细胞的相对频率降低，类别转换记忆B细胞同种型伊加、IgG和IgE增加。最后，使用来自135名前女性吸烟者的数据，我们发现，与主动吸烟相关的免疫特征的相对频率通常在戒烟后完全恢复，除了CD8+和CD8+记忆T细胞的亚群，它们持续部分改变。我们的研究结果与以前的研究结果一致，并为吸烟如何使白细胞亚群比例向慢性炎症方向发展提供了进一步的证据。
Tobacco smoking is known to impact circulating levels of major immune cells populations, but its effect on specific immune cell subsets remains poorly understood. Here, using high-resolution data from 223 healthy women (25 current and 198 never smokers), we investigated the association between smoking status and 35,651 immune traits capturing immune cell subset frequencies. Our results confirmed that active tobacco smoking is associated with increased frequencies of circulating CD8+ T cells expressing the CD25 activation marker. Moreover, we identified novel associations between smoking status and relative abundances of CD8+ CD25+ memory T cells, CD8+ memory T cells expressing the CCR4 chemokine receptor, and CD4+CD8+ (double-positive) CD25+ T cells. We also observed, in current smokers, a decrease in the relative frequencies of CD4+ T cells expressing the CD38 activation marker and an increase in class-switched memory B cell isotypes IgA, IgG, and IgE. Finally, using data from 135 former female smokers, we showed that the relative frequencies of immune traits associated with active smoking are usually completely restored after smoking cessation, with the exception of subsets of CD8+ and CD8+ memory T cells, which persist partially altered. Our results are consistent with previous findings and provide further evidence on how tobacco smoking shapes leukocyte cell subsets proportion toward chronic inflammation.
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影响因子：
8
作者：
Hong MJ;Gu BH;Madison MC;Landers C;Tung HY;Kim M;Yuan X;You R;Machado AA;Gilbert BE;Soroosh P;Elloso M;Song L;Chen M;Corry DB;Diehl G;Kheradmand F
通讯作者：
Kheradmand F
影响因子：
7.3
作者：
Churlaud G;Pitoiset F;Jebbawi F;Lorenzon R;Bellier B;Rosenzwajg M;Klatzmann D
通讯作者：
Klatzmann D
影响因子：
24.3
作者：
Brandsma, Corry-Anke;Kerstjens, Huib A. M.;Timens, Wim
通讯作者：
Timens, Wim
影响因子：
5.5
作者：
Jackson DA;Elsawa SF
通讯作者：
Elsawa SF
影响因子：
7.7
作者：
Lessov-Schlaggar, Christina N.;Pang, Zengchang;Lee, Liming
通讯作者：
Lee, Liming