Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts.
Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts.
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DOI：
10.1289/ehp.1104526
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发表时间：
2012-08
影响因子：
10.4
通讯作者：
Maggiolini M
中科院分区：
文献类型：
--
作者：
Pupo M;Pisano A;Lappano R;Santolla MF;De Francesco EM;Abonante S;Rosano C;Maggiolini M
Background: Bisphenol A (BPA) is the principal constituent of baby bottles, reusable water bottles, metal cans, and plastic food containers. BPA exerts estrogen-like activity by interacting with the classical estrogen receptors (ERα and ERβ) and through the G protein-coupled receptor (GPR30/GPER). In this regard, recent studies have shown that GPER was involved in the proliferative effects induced by BPA in both normal and tumor cells. Objectives: We studied the transduction signaling pathways through which BPA influences cell proliferation and migration in human breast cancer cells and cancer-associated fibroblasts (CAFs). Methods and results: We used as a model system SKBR3 breast cancer cells and CAFs that lack the classical ERs. Specific pharmacological inhibitors and gene-silencing procedures were used to show that BPA induces the expression of the GPER target genes c-FOS, EGR-1, and CTGF through the GPER/EGFR/ERK transduction pathway in SKBR3 breast cancer cells and CAFs. Moreover, we observed that GPER is required for growth effects and migration stimulated by BPA in both cell types. Conclusions: Results indicate that GPER is involved in the biological action elicited by BPA in breast cancer cells and CAFs. Hence, GPER-mediated signaling should be included among the transduction mechanisms through which BPA may stimulate cancer progression.
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影响因子：
4.8
作者：
Kuiper, GGJM;Lemmen, JG;Gustafsson, JÄ
通讯作者：
Gustafsson, JÄ
影响因子：
4.1
作者：
Mlynarcíková, A;Kolena, J;Scsuková, S
通讯作者：
Scsuková, S
影响因子：
10.4
作者：
Lapensee EW;Tuttle TR;Fox SR;Ben-Jonathan N
通讯作者：
Ben-Jonathan N
通过GPR30的雌激素信号传导和基因表达的机制。
影响因子：
4.1
作者：
Prossnitz, Eric R.;Maggiolini, Marcello
通讯作者：
Maggiolini, Marcello
影响因子：
11.2
作者：
Madeo, Antonio;Maggiolini, Marcello
通讯作者：
Maggiolini, Marcello