A Case of COVID-19 Vaccine Causing a Myasthenia Gravis Crisis.
A Case of COVID-19 Vaccine Causing a Myasthenia Gravis Crisis.
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新冠肺炎疫苗致重症肌无力危象1例。
DOI：
10.7759/cureus.15581
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Grist W
中科院分区：
文献类型：
--
作者：
Tagliaferri AR;Narvaneni S;Azzam MH;Grist W
重症肌无力是一种罕见的神经肌肉接头疾病，随后影响延髓，呼吸和四肢骨骼肌。它是一种自身免疫性疾病，其中抗体靶向乙酰胆碱受体（AChR），阻止肌肉收缩期间兴奋性级联的传输。重症肌无力通常使用乙酰胆碱酯酶抑制剂、类固醇、免疫抑制剂和/或胸腺切除术得到良好控制。然而，急性加重可由感染或药物引起。这在2019冠状病毒病（COVID-19）大流行期间尤为重要，已知重症肌无力患者的预后较差。我们报告了Moderna COVID-19疫苗引起的非常罕见的重症肌无力危象。
Myasthenia gravis is a rare disease of the neuromuscular junction subsequently affecting the bulbar, respiratory, and extremity skeletal muscles. It is an autoimmune disease in which antibodies target the acetylcholine receptor (AChR), preventing transmission of the excitatory cascade during muscle contraction. Myasthenia gravis is typically well controlled using acetylcholinesterase inhibitors, steroids, immunosuppressant agents, and/or thymectomies. However, exacerbations can be induced by infection or medications. This is particularly important during the coronavirus disease 2019 (COVID-19) pandemic in which myasthenia gravis patients have been known to have poorer outcomes. We report a very rare presentation of a myasthenia gravis crisis induced by the Moderna COVID-19 vaccine.
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