Sex differences in opioid analgesia and addiction: interactions among opioid receptors and estrogen receptors.
Sex differences in opioid analgesia and addiction: interactions among opioid receptors and estrogen receptors.
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DOI：
10.1186/1744-8069-9-45
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发表时间：
2013-09-08
期刊：
影响因子：
3.3
通讯作者：
Ho IK
中科院分区：
文献类型：
--
作者：
Lee CW;Ho IK
阿片类药物被广泛用作止痛药，也因成瘾药物而臭名昭着。阿片类镇痛和成瘾的性别差异已在人类受试者和动物模型中报道和研究。然而，男性和女性之间差异的分子机制仍然不清楚。在这里，我们回顾了文献描述的性别差异的镇痛反应和成瘾倾向的临床相关阿片类药物。阿片类药物，雌激素，阿片受体和雌激素受体之间的相互作用也进行了评估。我们推测，性别差异部分源于雌激素和阿片受体之间的串扰时，刺激外源性阿片类药物，可能通过共同的第二信使和下游基因转录调控。
Opioids are widely used as the pain reliever and also notorious for being addictive drugs. Sex differences in the opioid analgesia and addiction have been reported and investigated in human subjects and animal models. Yet, the molecular mechanism underlying the differences between males and females is still unclear. Here, we reviewed the literature describing the sex differences in analgesic responses and addiction liabilities to clinically relevant opioids. The reported interactions among opioids, estrogens, opioid receptors, and estrogen receptors are also evaluated. We postulate that the sex differences partly originated from the crosstalk among the estrogen and opioid receptors when stimulated by the exogenous opioids, possibly through common secondary messengers and the downstream gene transcriptional regulators.
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影响因子：
11.2
作者：
Ariazi EA;Brailoiu E;Yerrum S;Shupp HA;Slifker MJ;Cunliffe HE;Black MA;Donato AL;Arterburn JB;Oprea TI;Prossnitz ER;Dun NJ;Jordan VC
通讯作者：
Jordan VC
影响因子：
4.7
作者：
BAAMONDE, AI;HIDALGO, A;ANDRESTRELLES, F
通讯作者：
ANDRESTRELLES, F
DOI：
10.1073/pnas.91.18.8517
发表时间：
1994-08-30
影响因子：
11.1
作者：
ARONICA, SM;KRAUS, WL;KATZENELLENBOGEN, BS
通讯作者：
KATZENELLENBOGEN, BS
影响因子：
8.8
作者：
Aubrun, F;Salvi, N;Riou, B
通讯作者：
Riou, B
影响因子：
5
作者：
BANERJEE, P;CHATTERJEE, TK;GHOSH, JJ
通讯作者：
GHOSH, JJ