Aberrant beta-band brain connectivity predicts speech motor planning deficits in post-stroke aphasia.
Aberrant beta-band brain connectivity predicts speech motor planning deficits in post-stroke aphasia.
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DOI：
10.1016/j.cortex.2022.07.001
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发表时间：
2022-10
期刊：
影响因子：
3.6
通讯作者：
Behroozmand, Roozbeh
中科院分区：
文献类型：
--
作者：
Sarmukadam, Kimaya;Behroozmand, Roozbeh
言语产生障碍可能对左半球卒中失语症幸存者的整体生活质量产生破坏性影响;然而，在该临床人群中，在言语产生开始之前激活的言语运动规划网络中的神经缺陷的研究很少。在本研究中，我们研究了失语症参与者与言语发作前对照者在低β（13-20 Hz）和高β（21-30 Hz）频段神经振荡中言语准备和规划的定向脑连接相关性。同时记录了33名中风后失语症患者和22名神经功能完好的对照者在进行语音产生任务时的脑电图（EEG）数据。使用格兰杰因果关系，计算了在涉及感觉运动整合和言语规划的额-额、额-中央和额-顶叶网络内的电极对之间的脑连接。在中风后参与者中进一步进行临床评估，以测量与失语症相关的语言障碍的严重程度。与言语产生开始前的对照组相比，卒中后参与者的左顶-中央和顶-额叶以及右额-额叶和额-中央电极的低β和高β带内半球内连通性增加。此外，我们发现高β带内半球间中央-中央连接性降低与失语症严重程度呈负相关，而高β带内顶叶-额叶连接性增加与失语症严重程度呈正相关。这些研究结果表明，左半球中风的参与者在言语产生的计划阶段在左右半球的低β和高β带内表达异常的大脑连接，并且这些缺陷与他们语言障碍的特定方面相关，正如他们因失语症引起的临床症状所示。
Impairments in speech production can have devastating effects on the overall quality of life in left-hemisphere stroke survivors with aphasia; however, there is a paucity of research focusing on neural deficits in speech motor planning networks that are activated prior to the onset of speech production in this clinical population. In the present study, we examined directional brain connectivity correlates of speech preparation and planning in low-β (13–20 Hz) and high-β (21–30 Hz) band neural oscillations in participants aphasia compared with controls prior to the onset of speech. Electroencephalographic (EEG) data were concurrently recorded from 33 participants with post-stroke aphasia and 22 neurologically intact controls while they engaged in speech production tasks. Using Granger causality, brain connectivity was calculated between electrode pairs that fell within fronto-frontal, fronto-central, and fronto-parietal networks implicated in sensorimotor integration and speech planning. Clinical assessment was further conducted in post-stroke participants to measure the severity of language impairment associated with aphasia. Increased intra-hemispheric connectivity was found within low- and high-β bands in the left parieto-central and parieto-frontal as well as the right fronto-frontal and fronto-central electrodes in post-stroke participants compared with controls prior to the onset of speech production. In addition, we found that decreased inter-hemispheric centro-central connectivity within high-β band was negatively correlated with aphasia severity whereas increased parieto-frontal connectivity within high-β band was positively correlated with aphasia severity. These findings suggest that participants with left-hemisphere stroke express aberrant brain connectivity within low- and high-β bands in both left and right hemispheres during the planning phase of speech production, and that these deficits are associated with specific aspects of their language impairment, as indicated by their clinical symptoms due to aphasia.
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DOI：
10.1073/pnas.0308538101
发表时间：
2004-06-29
影响因子：
11.1
作者：
Brovelli, A;Ding, MZ;Bressler, SL
通讯作者：
Bressler, SL
影响因子：
3
作者：
Bastos AM;Schoffelen JM
通讯作者：
Schoffelen JM
影响因子：
2.4
作者：
Burnett, TA;Freedland, MB;Hain, TC
通讯作者：
Hain, TC
影响因子：
1.7
作者：
Flowers, Heather L.;Silver, Frank L.;Martino, Rosemary
通讯作者：
Martino, Rosemary
影响因子：
5.7
作者：
Behroozmand R;Phillip L;Johari K;Bonilha L;Rorden C;Hickok G;Fridriksson J
通讯作者：
Fridriksson J