Sensorimotor impairment of speech auditory feedback processing in aphasia.
Sensorimotor impairment of speech auditory feedback processing in aphasia.
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DOI：
10.1016/j.neuroimage.2017.10.014
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发表时间：
2018-01-15
期刊：
影响因子：
5.7
通讯作者：
Fridriksson J
中科院分区：
文献类型：
--
作者：
Behroozmand R;Phillip L;Johari K;Bonilha L;Rorden C;Hickok G;Fridriksson J
我们通过使用改变的听觉反馈（AAF）范式研究中风后失语症患者，研究了参与言语感觉运动处理的大脑网络。我们结合病变症状映射分析和行为测试来检查言语感觉运动缺陷的普遍性及其与皮质损伤的关系。十六名患有失语症的参与者和十六名神经完好的个体在 AAF 下完成了一项言语任务。该任务涉及在实时音调变化的听觉反馈变化下产生语音元音。这项任务为每个人补偿语音听觉反馈不匹配（错误）的能力提供了客观的衡量标准。结果表明，与对照组相比，失语症参与者对 AAF 的补偿性言语反应显着减弱。我们观察到，在失语症组中，言语重复任务得分较低的受试者表现出更大程度的反应减弱。病变症状映射分析显示，AAF 反应减弱的起始阶段（50-150 ms）是通过颞上回和中回听觉皮层区域的损伤来预测的，而 AAF 反应减弱的上升阶段（150-250 ms）和峰值（250-350 ms）分别是通过额下回和边缘上回区域的损伤来预测的。这些发现表明，听觉、运动和听觉-运动整合网络的损伤与语音错误处理的感觉运动功能受损有关。我们认为，与 AAF 反应的时间特定成分相关的大脑区域所揭示的感觉运动整合网络与失语症患者的言语处理和言语障碍的特定方面（尤其是重复缺陷）有关。
We investigated the brain network involved in speech sensorimotor processing by studying patients with post-stroke aphasia using an altered auditory feedback (AAF) paradigm. We combined lesion-symptom-mapping analysis and behavioral testing to examine the pervasiveness of speech sensorimotor deficits and their relationship with cortical damage. Sixteen participants with aphasia and sixteen neurologically intact individuals completed a speech task under AAF. The task involved producing speech vowel sounds under the real-time pitch-shifted auditory feedback alteration. This task provided an objective measure for each individual’s ability to compensate for mismatch (error) in speech auditory feedback. Results indicated that compensatory speech responses to AAF were significantly diminished in participants with aphasia compared with control. We observed that within the aphasic group, subjects with lower scores on the speech repetition task exhibited greater degree of diminished responses. Lesion-symptom-mapping analysis revealed that the onset phase (50–150 ms) of diminished AAF responses were predicted by damage to auditory cortical regions within the superior and middle temporal gyrus, whereas the rising phase (150–250 ms) and the peak (250–350 ms) of diminished AAF responses were predicted with damage to the inferior frontal gyrus and supramarginal gyrus areas, respectively. These findings suggest that damage to the auditory, motor, and auditory-motor integration networks are associated with impaired sensorimotor function for speech error processing. We suggest that a sensorimotor integration network, as revealed by brain regions related to temporal specific components of AAF responses, is related to speech processing and specific aspects of speech impairment, notably repetition deficits, in individuals with aphasia.
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影响因子：
2.9
作者：
Basilakos A;Fillmore PT;Rorden C;Guo D;Bonilha L;Fridriksson J
通讯作者：
Fridriksson J
DOI：
10.1523/jneurosci.2227-10.2010
发表时间：
2010-09-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fridriksson J
通讯作者：
Fridriksson J
影响因子：
5.7
作者：
Behroozmand R;Shebek R;Hansen DR;Oya H;Robin DA;Howard MA 3rd;Greenlee JD
通讯作者：
Greenlee JD
影响因子：
2.5
作者：
Buchsbaum, Bradley R.;Baldo, Juliana;Hickok, Gregory
通讯作者：
Hickok, Gregory
影响因子：
14.5
作者：
Fridriksson, Julius;Guo, Dazhou;Rorden, Chris
通讯作者：
Rorden, Chris