Temporally and anatomically specific contributions of the human amygdala to threat and safety learning.
Temporally and anatomically specific contributions of the human amygdala to threat and safety learning.
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DOI：
10.1073/pnas.2204066119
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发表时间：
2022-06-28
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
巴甫洛夫威胁学习是理解焦虑和创伤相关精神病理学基础的大脑系统的主要翻译模型。传统上，杏仁核在这种重要的跨物种学习形式中发挥着核心作用。然而，最近的人类神经影像学工作揭示了关于人类杏仁核在威胁和安全学习中的作用的不一致的发现。为了解决这一差异，我们在大样本的人类参与者中检查了杏仁核对威胁预测线索的反应。我们发现了强有力的证据杏仁核的反应，在威胁条件反射，并进一步，这些反应发生在一个时间和解剖学上的具体方式。我们的研究结果揭示了人类杏仁核参与联想学习的明确证据，并提供了深入了解为什么一些神经影像学工作产生了模棱两可的结果。众所周知，啮齿类动物杏仁核亚区的神经可塑性对巴甫洛夫威胁条件反射和安全学习至关重要。然而，在人类神经影像学研究中观察到的结果不太一致。在这里，我们确定和测试三个重要的因素，可能有助于这些差异：杏仁核的威胁条件反射反应的时间轮廓，杏仁核的威胁条件反射和安全学习过程中的反应的解剖特异性，并没有足够的力量来识别这些反应。我们结合了多项研究的数据，使用经过充分验证的人类威胁条件反射范式来检查杏仁核在威胁条件反射和安全学习过程中的参与。在601人中，我们发现，两个杏仁核子区域跟踪条件刺激与厌恶性休克在早期条件反射，而只有一个表现出延迟响应的刺激不与休克配对。我们的研究结果确定了跨物种的相似性，在时间和解剖特定的杏仁核的贡献，威胁和安全的学习，肯定人类杏仁核参与联想学习，并强调未来的人类联想学习研究的重要因素。
Pavlovian threat learning is a primary translational model for understanding the brain systems that underlie anxiety and trauma-related psychopathology. The amygdala has traditionally played a central role in this important form of learning across species. However, recent human neuroimaging work has revealed inconsistent findings regarding the role of human amygdala in threat and safety learning. To address this discrepancy, we examined amygdala responses to threat-predictive cues in a large sample of human participants. We found robust evidence for amygdala responses during threat conditioning and, further, that these responses occurred in a temporally and anatomically specific manner. Our results reveal clear evidence of human amygdala involvement in associative learning and offer insight into why some neuroimaging work has yielded equivocal findings. Neural plasticity in subareas of the rodent amygdala is widely known to be essential for Pavlovian threat conditioning and safety learning. However, less consistent results have been observed in human neuroimaging studies. Here, we identify and test three important factors that may contribute to these discrepancies: the temporal profile of amygdala response in threat conditioning, the anatomical specificity of amygdala responses during threat conditioning and safety learning, and insufficient power to identify these responses. We combined data across multiple studies using a well-validated human threat conditioning paradigm to examine amygdala involvement during threat conditioning and safety learning. In 601 humans, we show that two amygdala subregions tracked the conditioned stimulus with aversive shock during early conditioning while only one demonstrated delayed responding to a stimulus not paired with shock. Our findings identify cross-species similarities in temporal- and anatomical-specific amygdala contributions to threat and safety learning, affirm human amygdala involvement in associative learning and highlight important factors for future associative learning research in humans.
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DOI：
10.1093/cercor/bhq186
发表时间：
2011-07
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Deen B;Pitskel NB;Pelphrey KA
通讯作者：
Pelphrey KA
影响因子：
25
作者：
King M;Hernandez-Castillo CR;Poldrack RA;Ivry RB;Diedrichsen J
通讯作者：
Diedrichsen J
影响因子：
3.4
作者：
Boll, Sabrina;Gamer, Matthias;Buechel, Christian
通讯作者：
Buechel, Christian
影响因子：
16.2
作者：
LaBar, KS;Gatenby, JC;Phelps, EA
通讯作者：
Phelps, EA
影响因子：
56.9
作者：
BECHARA, A;TRANEL, D;DAMASIO, AR
通讯作者：
DAMASIO, AR