The Effect of Developmental Pleiotropy on the Evolution of Insect Immune Genes.
The Effect of Developmental Pleiotropy on the Evolution of Insect Immune Genes.
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DOI：
10.1093/gbe/evad044
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发表时间：
2023-03-03
影响因子：
3.3
通讯作者：
Tate, Ann T.
中科院分区：
文献类型：
--
作者：
Williams, Alissa M.;Ngo, Thi Minh;Figueroa, Veronica E.;Tate, Ann T.
在不断变化的病原体暴露中生存的压力解释了经常观察到的免疫基因是许多分类群基因组中进化最快的基因之一，但有趣的是，免疫基因的比例似乎也处于纯化选择之下。虽然免疫基因进化特征的差异通常归因于与微生物的基因特异性相互作用的差异，但这种解释忽略了免疫基因参与其他生物过程的可能性，这些生物过程可能会多效性地限制适应性选择。在这项研究中，我们分析了现有的转录组和基因组数据从果蝇和相关物种来测试的假设，有大量的多效性重叠的发育和免疫功能的基因参与免疫信号和多效性将与更强的签名的进化约束。我们的研究结果表明，多效性免疫基因的进化速度比那些没有已知的发展功能，约束的签名是特别强大的多效性免疫基因，广泛表达的生命阶段。这些结果支持了一个普遍但未经检验的假设，即多效性可以限制免疫系统的进化，提出了关于在需要快速适应不断变化的病原体压力的系统中保持多效性的好处的新的基本问题。
The pressure to survive ever-changing pathogen exposure explains the frequent observation that immune genes are among the fastest evolving in the genomes of many taxa, but an intriguing proportion of immune genes also appear to be under purifying selection. Though variance in evolutionary signatures of immune genes is often attributed to differences in gene-specific interactions with microbes, this explanation neglects the possibility that immune genes participate in other biological processes that could pleiotropically constrain adaptive selection. In this study, we analyzed available transcriptomic and genomic data from Drosophila melanogaster and related species to test the hypothesis that there is substantial pleiotropic overlap in the developmental and immunological functions of genes involved in immune signaling and that pleiotropy would be associated with stronger signatures of evolutionary constraint. Our results suggest that pleiotropic immune genes do evolve more slowly than those having no known developmental functions and that signatures of constraint are particularly strong for pleiotropic immune genes that are broadly expressed across life stages. These results support the general yet untested hypothesis that pleiotropy can constrain immune system evolution, raising new fundamental questions about the benefits of maintaining pleiotropy in systems that need to rapidly adapt to changing pathogen pressures.
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影响因子：
7.7
作者：
Kinsler G;Geiler-Samerotte K;Petrov DA
通讯作者：
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作者：
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通讯作者：
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DOI：
10.1098/rstb.2019.0066
发表时间：
2019-10-14
影响因子：
6.3
作者：
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通讯作者：
Tate, Ann T.
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通讯作者：
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