Carbon Dioxide and the Carbamate Post-Translational Modification.

Carbon Dioxide and the Carbamate Post-Translational Modification.
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DOI:
10.3389/fmolb.2022.825706
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发表时间:
2022
影响因子:
5
通讯作者:
Cann MJ
Cann MJ
中科院分区:
生物学3区
文献类型:
--
作者:
Blake LI;Cann MJ

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二氧化碳对生命至关重要。它在每个生命过程的开始作为光合作用的底物。它是在每一个生命过程结束时作为死后腐烂的产物。因此,这种气体调节细胞化学反应、运输、维持细胞环境和行为等多种过程并不奇怪。二氧化碳是与作物对环境变化的反应、虫媒传播疾病和公共卫生相关的具有战略重要性的研究目标。然而,我们对二氧化碳与细胞的直接相互作用知之甚少。通过二氧化碳对N-末端α-氨基或赖氨酸α-氨基的亲核攻击介导的氨基甲酸酯翻译后修饰是二氧化碳可能改变蛋白质功能以形成传感和信号传导机制的一部分的一种机制。我们详细介绍了已知的蛋白质氨基甲酸酯,包括他们的发现历史。此外,我们描述了最近的研究新技术来隔离这个有问题的翻译后修饰。
Carbon dioxide is essential for life. It is at the beginning of every life process as a substrate of photosynthesis. It is at the end of every life process as the product of post-mortem decay. Therefore, it is not surprising that this gas regulates such diverse processes as cellular chemical reactions, transport, maintenance of the cellular environment, and behaviour. Carbon dioxide is a strategically important research target relevant to crop responses to environmental change, insect vector-borne disease and public health. However, we know little of carbon dioxide’s direct interactions with the cell. The carbamate post-translational modification, mediated by the nucleophilic attack by carbon dioxide on N-terminal α-amino groups or the lysine ɛ-amino groups, is one mechanism by which carbon dioxide might alter protein function to form part of a sensing and signalling mechanism. We detail known protein carbamates, including the history of their discovery. Further, we describe recent studies on new techniques to isolate this problematic post-translational modification.
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