Preoperative Neutrophil-to-Lymphocyte Ratio as a New Prognostic Marker in Hepatocellular Carcinoma after Curative Resection.
Preoperative Neutrophil-to-Lymphocyte Ratio as a New Prognostic Marker in Hepatocellular Carcinoma after Curative Resection.
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术前中性粒细胞与淋巴细胞比率作为肝细胞癌根治性切除后新的预后标志物
DOI：
10.1016/j.tranon.2014.02.011
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发表时间：
2014-04
影响因子：
5
通讯作者：
He, Songqing
中科院分区：
文献类型：
--
作者：
Liao, Weijia;Zhang, Jingmei;Zhu, Qun;Qin, Liling;Yao, Wenmin;Lei, Biao;Shi, Wuxiang;Yuan, Shengguang;Tahir, Syed Abdul;Jin, Junfei;He, Songqing
背景技术背景：术前外周血嗜中性粒细胞/淋巴细胞比值（NLR）被认为是预测肝细胞癌（HCC）预后的指标。然而，几项研究中的NLR临界值并不一致。本研究旨在探讨肝癌切除患者术前NLR与临床病理特征及预后的相关性。方法：回顾性分析256例肝癌根治性切除术患者的临床资料。将患者分为低NLR组（NLR ≤ 2.31）和高NLR组（NLR > 2.31）。进行单因素分析以评估影响患者无病生存期（DFS）和总生存期（OS）的临床病理特征。通过使用考克斯回归的多变量分析进一步分析显著变量。采用Kaplan-Meier法评估DFS和OS率。研究结果：NLR值与肿瘤大小、临床TNM分期、门静脉癌栓（PVTT）、远处转移和AST有关。NLR > 2.31、肿瘤大小> 5cm、多发肿瘤数、TNM分期Ⅲ ~ Ⅳ期、PVTT、远处转移、AST > 40 U/l是DFS和OS较差的预测因子，NLR > 2.31、肿瘤大小> 5cm、TNM分期Ⅲ ~ Ⅳ期、AST > 40 U/l是DFS和OS的独立预测因子。术前NLR > 2.31是HCC患者肝切除术后DFS和OS的不良预测因子。这项研究表明，NLR可能是一种新的预后生物标志物肝癌根治性切除术后。
BACKGROUND: Preoperative peripheral blood neutrophil-to-lymphocyte ratio (NLR) has been proposed to predict prognosis of hepatocellular carcinoma (HCC). However, the cutoff value of NLR in several studies is not consistent. This study aims to investigate the correlation of preoperative NLR with clinicopathologic features and the prognosis in patients who have undergone resection for HCC. METHODS: Clinical data of 256 patients with HCC who underwent radical hepatectomy were retrospectively analyzed. The patients were divided into the low-NLR group (NLR ≤ 2.31) and the high-NLR group (NLR > 2.31). A univariate analysis was performed to assess clinicopathologic characteristics that influenced disease-free survival (DFS) and overall survival (OS) in patients. The significant variables were further analyzed by a multivariate analysis using Cox regression. The Kaplan-Meier method was used to assess the DFS and OS rate. RESULTS: The value of NLR was associated with tumor size, clinical tumor-node-metastasis (TNM) stage, portal vein tumor thrombus (PVTT), distant metastasis, and aspartate aminotransferase (AST) in HCC. NLR > 2.31, size of tumor > 5 cm, number of multiple tumors, III-IV of TNM stage, PVTT, distant metastasis, and AST > 40 U/l were predictors of poorer DFS and OS. NLR > 2.31, size of tumor > 5 cm, III-IV of TNM stage, and AST > 40 U/l were independent predictors of DFS and OS. CONCLUSION: Preoperative NLR > 2.31 was an adverse predictor of DFS and OS in HCC after hepatectomy. This study suggested that NLR might be a novel prognostic biomarker in HCC after curative resection.
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影响因子：
9
作者：
Nathan, Hari;Schulick, Richard D.;Pawlik, Timothy M.
通讯作者：
Pawlik, Timothy M.
影响因子：
2.8
作者：
Ding, Pei-Rong;An, Xin;Pan, Zhi-Zhong
通讯作者：
Pan, Zhi-Zhong
影响因子：
3.7
作者：
Azab, Basem;Bhatt, Vijaya R.;Widmann, Warren D.
通讯作者：
Widmann, Warren D.
影响因子：
3.8
作者：
Oh BS;Jang JW;Kwon JH;You CR;Chung KW;Kay CS;Jung HS;Lee S
通讯作者：
Lee S
HURP表达辅助风险评分确定了早期肝癌中可区分的亚组的预后。
影响因子：
3.7
作者：
Chang ML;Lin SM;Yeh CT
通讯作者：
Yeh CT