A niche for axial stem cells - A cellular perspective in amniotes.
A niche for axial stem cells - A cellular perspective in amniotes.
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DOI：
10.1016/j.ydbio.2022.06.015
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发表时间：
2022-10
影响因子：
2.7
通讯作者：
Stern, Claudio D.
中科院分区：
文献类型：
--
作者：
Solovieva, Tatiana;Wilson, Valerie;Stern, Claudio D.
鸟类和哺乳动物的头-尾轴是从包含节的尾端的生长区发展而来的。这个生长区然后形成尾芽。标记实验表明，虽然许多细胞离开节点和尾芽，以促进轴（脊索，底板）和近轴（体节）结构，一些细胞仍然驻留在节点和尾芽。这些细胞可能是常驻轴干细胞吗？如果是这样的话，节点和尾芽是否代表了一个指导性的干细胞小生境，指定和维持这些干细胞？连续移植和单细胞标记研究支持自我更新干细胞的存在，异位移植表明淋巴结可以指导这种自我更新行为。然而，只有单细胞操作可以揭示自我更新行为是否发生在细胞群体水平（不对称或对称细胞分裂）或单细胞水平（仅不对称分裂）。我们结合联合收割机的数据常驻细胞在节点和尾芽和审查的背景下，在鸡和小鼠的轴向发展，总结我们目前的理解轴向干细胞及其生态位，并强调未来的方向感兴趣。鸟类和哺乳动物的头-尾轴起源于尾部生长区，包括节点。这个生长区然后形成尾芽。这篇综述探讨了证据表明，节点和尾芽包含居民轴干细胞。我们联合收割机的数据在结和尾芽和讨论鸡和小鼠。我们强调未来的兴趣方向。
The head-tail axis in birds and mammals develops from a growth zone in the tail-end, which contains the node. This growth zone then forms the tailbud. Labelling experiments have shown that while many cells leave the node and tailbud to contribute to axial (notochord, floorplate) and paraxial (somite) structures, some cells remain resident in the node and tailbud. Could these cells be resident axial stem cells? If so, do the node and tailbud represent an instructive stem cell niche that specifies and maintains these stem cells? Serial transplantation and single cell labelling studies support the existence of self-renewing stem cells and heterotopic transplantations suggest that the node can instruct such self-renewing behaviour. However, only single cell manipulations can reveal whether self-renewing behaviour occurs at the level of a cell population (asymmetric or symmetric cell divisions) or at the level of single cells (asymmetric divisions only). We combine data on resident cells in the node and tailbud and review it in the context of axial development in chick and mouse, summarising our current understanding of axial stem cells and their niche and highlighting future directions of interest. The head-tail axis in birds and mammals arises from a caudal growth zone, containing the node. This growth zone then forms the tailbud. This review examines the evidence that the node and tailbud contain resident axial stem cells. We combine data on resident cells in the node and tailbud and discuss for chick and mouse. We highlight future directions of interest.
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