Interactions between the mGluR2/3 agonist, LY379268, and cocaine on in vivo neurochemistry and behavior in squirrel monkeys.
Interactions between the mGluR2/3 agonist, LY379268, and cocaine on in vivo neurochemistry and behavior in squirrel monkeys.
复制标题
DOI：
10.1016/j.pbb.2009.08.011
复制
发表时间：
2009-11
影响因子：
3.6
通讯作者：
Howell, Leonard L.
中科院分区：
文献类型：
--
作者：
Bauzo, Rayna M.;Kimmel, Heather L.;Howell, Leonard L.
关键词：
最近的证据表明，II 类代谢型谷氨酸受体（mGluR2 和 mGluR3）可能在可卡因成瘾的病理学中发挥作用。本研究的目的是确定 mGluR2/3 激动剂 LY379268 对可卡因诱导的非人类灵长类动物 DA 神经化学变化的影响。此外，本研究旨在确定 DA 神经化学变化是否与 LY379268 诱导的可卡因行为效应变化相关。在有意识的松鼠猴（n=4）中进行体内微透析，以监测可卡因诱导的尾状核细胞外 DA 的变化。对不同组的受试者进行刺激终止固定间隔时间表（n = 4）或可卡因自我给药二阶时间表（n = 5）的培训，以分别表征行为刺激和强化效果。 LY379268 显着减弱可卡因诱导的 DA 增加。 LY379268 还可以在较短的预处理时间后显着减弱可卡因诱导的行为刺激作用，但在较长的预处理时间后则不会。可卡因自我给药显着减弱，但仅在 LY379268 的中间预处理剂量下。此外，LY379268 并未显着减弱先前熄灭的可卡因自我给药的恢复。因此，药物对神经化学的相互作用与行为测量没有很好的相关性。
Recent evidence indicates that group II metabotropic glutamate receptors (mGluR2 and mGluR3) may play a role in the pathology of cocaine addiction. The purpose of the current study was to determine the effects of the mGluR2/3 agonist, LY379268, on cocaine-induced changes in DA neurochemistry in nonhuman primates. Furthermore, the current study aimed to determine if changes in DA neurochemistry would correlate with LY379268-induced changes in the behavioral effects of cocaine. In vivo microdialysis was conducted in conscious squirrel monkeys (n=4) in order to monitor cocaine-induced changes in extracellular DA in the caudate nucleus. Separate groups of subjects were trained on a fixed-interval schedule of stimulus termination (n=4) or a second-order schedule of cocaine self-administration (n=5) to characterize the behavioral-stimulant and reinforcing effects, respectively. LY379268 significantly attenuated cocaine-induced increases in DA. LY379268 also significantly attenuated cocaine-induced behavioral-stimulant effects following a short pretreatment time, but not following a longer pretreatment time. Cocaine self-administration was significantly attenuated but only at an intermediate pretreatment dose of LY379268. Moreover, reinstatement of previously extinguished cocaine self-administration was not significantly attenuated by LY379268. Hence, drug interactions on neurochemistry did not correlate well with behavioral measures.
登录
查看更多内容
影响因子：
2.9
作者：
Cartmell, J;Salhoff, CR;Schoepp, DD
通讯作者：
Schoepp, DD
影响因子：
16.2
作者：
OHISHI, H;OGAWAMEGURO, R;MIZUNO, N
通讯作者：
MIZUNO, N
影响因子：
4.7
作者：
David, HN;Abraini, JH
通讯作者：
Abraini, JH
影响因子：
--
作者：
Nakanishi, S;Nakajima, Y;Okada, M
通讯作者：
Okada, M
影响因子：
3.6
作者：
Ginsburg, BC;Kimmel, HL;Howell, LL
通讯作者：
Howell, LL