N,N'-dinitrosopiperazine-mediated AGR2 is involved in metastasis of nasopharyngeal carcinoma.
N,N'-dinitrosopiperazine-mediated AGR2 is involved in metastasis of nasopharyngeal carcinoma.
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DOI：
10.1371/journal.pone.0092081
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Tang F
中科院分区：
文献类型：
--
作者：
Li Y;Lu J;Peng Z;Tan G;Liu N;Huang D;Zhang Z;Duan C;Tang X;Tang F
Nasopharyngeal carcinoma (NPC) has a high metastatic character in the clinic, but its mechanism is not clear. As a carcinogen with organ specificity for the nasopharyngeal epithelium, N,N′-Dinitrosopiperazine (DNP) is involved in NPC metastasis. Herein, our data revealed that anterior gradient 2 (AGR2) was overexpressed in human NPC tissues, particularly in cervical lymph node metastatic NPC (LMNPC). High AGR2 expression was associated with NPC metastasis. Importantly, DNP induced AGR2 expression, and increased cell motility and invasion in the NPC cell line 6–10B. However, DNP-mediated cell motility and invasion was dramatically decreased when transfected with siRNA-AGR2. Further, AGR2 directly regulated cathepsin (CTS) B and D by binding them in vitro. These results indicate that DNP induces AGR2 expression, regulates CTSB and CTSD, increases cell motility and invasion, and promotes NPC tumor metastasis. Therefore, DNP-mediated AGR2 expression may be an important factor in prolific NPC metastasis.
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影响因子：
6.7
作者：
Kong QL;Hu LJ;Cao JY;Huang YJ;Xu LH;Liang Y;Xiong D;Guan S;Guo BH;Mai HQ;Chen QY;Zhang X;Li MZ;Shao JY;Qian CN;Xia YF;Song LB;Zeng YX;Zeng MS
通讯作者：
Zeng MS
影响因子：
1.5
作者：
Czyzewska, Jolanta;Guzinska-Ustymowicz, Katarzyna;Bandurski, Roman
通讯作者：
Bandurski, Roman
DOI：
10.1007/s00432-007-0264-3
发表时间：
2008-02-01
影响因子：
3.6
作者：
del Casar, Jose M.;Corte, Maria D.;Vizoso, Francisco J.
通讯作者：
Vizoso, Francisco J.
影响因子：
3.8
作者：
Jia WH;Luo XY;Feng BJ;Ruan HL;Bei JX;Liu WS;Qin HD;Feng QS;Chen LZ;Yao SY;Zeng YX
通讯作者：
Zeng YX
影响因子：
12.4
作者：
Gan, Y.;Zhao, X.;Zhao, X. T.
通讯作者：
Zhao, X. T.