Traditional Cantonese diet and nasopharyngeal carcinoma risk: a large-scale case-control study in Guangdong, China.
Traditional Cantonese diet and nasopharyngeal carcinoma risk: a large-scale case-control study in Guangdong, China.
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DOI：
10.1186/1471-2407-10-446
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发表时间：
2010-08-20
期刊：
影响因子：
3.8
通讯作者：
Zeng YX
中科院分区：
文献类型：
--
作者：
Jia WH;Luo XY;Feng BJ;Ruan HL;Bei JX;Liu WS;Qin HD;Feng QS;Chen LZ;Yao SY;Zeng YX
鼻咽癌在世界大部分地区是罕见的，但在中国南部，尤其是广东，鼻咽癌是一种常见的恶性肿瘤。饮食习惯被认为是几个鼻咽癌流行地区鼻咽癌风险的重要影响因素，并可能部分解释鼻咽癌发病的地理分布。在中国，过去几十年的快速经济发展已经极大地改变了中国人的主要生活方式和饮食习惯，需要重新评估饮食及其对这个鼻咽癌流行地区鼻咽癌风险的潜在影响。为了评价饮食因素与广东地区鼻咽癌发病风险的关系，中国进行了一项以医院为基础的大规模病例对照研究。1387例符合条件的病例和1459例频率匹配的对照被招募。使用Logistic回归模型估计优势比(OR)和相应的95%可信区间(CI)，并根据年龄、性别、教育程度、方言和居住家庭类型进行调整。研究结果表明：1)在儿童时期摄入频率最高的人群中，食用广式咸鱼、腌制蔬菜和腌制肉类与鼻咽癌发病风险显著相关，其优势比(OR)分别为2.45(95%CI：2.03~2.94)、3.17(95%CI：2.68~3.77)和2.09(95%CI：1.22~3.6)；2)食用新鲜水果与降低鼻咽癌风险相关(P=0.001)；3)饮用广式凉茶和慢煮汤与降低风险相关，在摄入频率最高的人群中，OR值分别为0.84(95%CI：0.68~1.03)和0.58(95%CI：0.47~0.72)。在多变量分析中，这些关联仍然显著。可以推断，广东人群既往确立的饮食危险因素仍然稳定，是导致鼻咽癌发病的原因之一。
Nasopharyngeal carcinoma (NPC) is rare in most parts of the world but is a common malignancy in southern China, especially in Guangdong. Dietary habit is regarded as an important modifier of NPC risk in several endemic areas and may partially explain the geographic distribution of NPC incidence. In China, rapid economic development during the past few decades has changed the predominant lifestyle and dietary habits of the Chinese considerably, requiring a reassessment of diet and its potential influence on NPC risk in this NPC-endemic area. To evaluate the association between dietary factors and NPC risk in Guangdong, China, a large-scale, hospital-based case-control study was conducted. 1387 eligible cases and 1459 frequency matched controls were recruited. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated using a logistic regression model, adjusting for age, sex, education, dialect, and habitation household type. Observations made include the following: 1) consumption of canton-style salted fish, preserved vegetables and preserved/cured meat were significantly associated with increased risk of NPC, with enhanced odds ratios (OR) of 2.45 (95% CI: 2.03-2.94), 3.17(95% CI: 2.68-3.77) and 2.09 (95% CI: 1.22-3.60) respectively in the highest intake frequency stratum during childhood; 2) consumption of fresh fruit was associated with reduced risk with a dose-dependent relationship (p = 0.001); and 3) consumption of Canton-style herbal tea and herbal slow-cooked soup was associated with decreased risk, with ORs of 0.84 (95% CI: 0.68-1.03) and 0.58 (95% CI: 0.47-0.72) respectively in the highest intake frequency stratum. In multivariate analyses, these associations remained significant. It can be inferred that previously established dietary risk factors in the Cantonese population are still stable and have contributed to the incidence of NPC.
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