Fetal growth restriction mice are more likely to exhibit depression‐like behaviors due to stress‐induced loss of dopaminergic neurons in the VTA
Fetal growth restriction mice are more likely to exhibit depression‐like behaviors due to stress‐induced loss of dopaminergic neurons in the VTA
复制标题
由于压力导致 VTA 中多巴胺能神经元的丧失，胎儿生长受限的小鼠更有可能表现出抑郁样行为
DOI：
10.1096/fj.202000534r
复制
发表时间：
2020-08
期刊：
影响因子：
--
通讯作者：
Jiu‐Hong Kang
中科院分区：
文献类型：
--
作者：
Li Ma;Meng‐Xue Tian;Qiao‐Yi Sun;Na‐Na Liu;Jian‐Feng Dong;Ke Feng;Yu‐Kang Wu;Yu‐Xi Wang;Gui‐Ying Wang;Wen Chen;Jia‐Jie Xi;Jiu‐Hong Kang
胎儿生长受限(FGR)是一种严重的围产期并发症，会增加患精神疾病的风险。为了探讨FGR小鼠在成年期发生精神疾病的机制，我们建立了FGR小鼠模型，FGR小鼠没有表现出明显的抑郁样行为，但在环境应激暴露后，FGR小鼠比对照组小鼠更容易表现出抑郁样行为。此外，FGR小鼠腹侧被盖区的多巴胺能神经元明显减少，但中缝背侧的5-羟色胺能神经元没有差异。RNA-seq分析表明，FGR小鼠中脑下调基因与多种精神疾病有关，尤其参与NMDAR活性的调节。此外，NMDAR拮抗剂美金刚可减轻FGR小鼠应激诱导的抑郁样行为。综上所述，我们的研究结果为未来FGR相关性抑郁症的研究和治疗提供了理论基础。
Fetal growth restriction (FGR) is a severe perinatal complication that can increase risk for mental illness. To investigate the mechanism by which FGR mice develop mental illness in adulthood, we established the FGR mouse model and the FGR mice did not display obvious depression‐like behaviors, but after environmental stress exposure, FGR mice were more likely to exhibit depression‐like behaviors than control mice. Moreover, FGR mice had significantly fewer dopaminergic neurons in the ventral tegmental area but no difference in serotoninergic neurons in the dorsal raphe. RNA‐seq analysis showed that the downregulated genes in the midbrain of FGR mice were associated with many mental diseases and were especially involved in the regulation of NMDA‐selective glutamate receptor (NMDAR) activity. Furthermore, the NMDAR antagonist memantine can relieve the stress‐induced depression‐like behaviors of FGR mice. In summary, our findings provide a theoretical basis for future research and treatment of FGR‐related depression.
登录
查看更多内容
影响因子：
25
作者：
Menard C;Pfau ML;Hodes GE;Kana V;Wang VX;Bouchard S;Takahashi A;Flanigan ME;Aleyasin H;LeClair KB;Janssen WG;Labonté B;Parise EM;Lorsch ZS;Golden SA;Heshmati M;Tamminga C;Turecki G;Campbell M;Fayad ZA;Tang CY;Merad M;Russo SJ
通讯作者：
Russo SJ
SIRT1/OCT6 轴失调导致环境压力诱发的神经感应缺陷
影响因子：
5.9
作者：
Li G;Jiapaer Z;Weng R;Hui Y;Jia W;Xi J;Wang G;Zhu S;Zhang X;Feng D;Liu L;Zhang X;Kang J
通讯作者：
Kang J
DOI：
10.1176/ajp.153.12.1637
发表时间：
1996-12
期刊：
The American journal of psychiatry
影响因子：
--
作者：
H. Hoek;E. Susser;Buck Ka;L. Lumey;S. Lin;J. Gorman
通讯作者：
H. Hoek;E. Susser;Buck Ka;L. Lumey;S. Lin;J. Gorman
DOI：
10.12659/msm.908422
发表时间：
2018-10-26
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Liu S;Xu S;Wang Z;Guo Y;Pan W;Shen Z
通讯作者：
Shen Z
影响因子：
2.7
作者：
Bogdanov, Volodymyr Borysovych;Bogdanova, Olena Viktorivna;Koulchitsky, Stanislav Vladimirovich;Chauvel, Virginie;Multon, Sylvie;Makarchuk, Mykola Yukhymovych;Brennan, Kevin Christopher;Renshaw, Perry Franklin;Schoenen, Jean
通讯作者：
Schoenen, Jean